Peptide Analogs for Drug Discovery

Synthesis of Side Products For Peptide Drug Development

Due to the intrinsic property of the peptide, it is a prerequisite in terms of quality control and safety to recognize the small amount of contaminants in the peptidic medicine. Idendification is readily achieved utilizing the synthetic replica of such contaminants as authentic samples. Chemical synthesis of the site-specifically modified peptide is often more difficult than that of the intact molecule. However, we offer any such compounds upon request by applying our vast knowledge of peptide synthesis and the general organic chemistry. Some of the modifications to consider from the structure of the peptide are shown below, all of which are the target of our synthetic chemists!

For example

Asp-X, Asn-X	Succinimide、β-Asp-X(iso-Asp-X)
Oxdation of Cys	Sulfinic acid [Cys(O₂H)], Sulfonic acid [Cys(O₃H)] Disulfide bond formation（dimer formation）
Oxdation of Met	Sulfoxide [Met(O)], Sulfone [Met(O₂)]
N-terminal Gln, Glu	Formation of Pyroglutamic acid （Pyr）
Hydrolysis	Deamidation of Asn, Gln, C-terminal amide Hydrolysis of ester bond Hydrolysis of peptide bond
Alkylation	Alkylation of Met, Cys, Tyr, Trp, His, etc
Acylation	Acylation of Ser, Thr, Tyr, etc Acylation of N-terminal amine, side chain amine(Lys)
Others	Short chain peptides, Deletion peptides, Insertion peptides Epimerization peptides, Branched peptides, Disulfide isomers