CLEAR resins (Cross-Linked Ethoxylate Acrylate Resins) were developed by George Barany and Maria Kempe at the University of Minnesota.1,2) These products retain the highly desirable solvation properties of polyethylene glycol (PEG) and PEG-linked products but can be handled with infinitely greater convenience. Unlike conventional liquid phase synthesis, developed by Bayer and Mutter in the 1970s3) and recently popularized by Janda in combinatorial synthesis4), CLEAR resins are highly cross-linked. They are produced in a bead form employing a large-scale suspension polymerization process developed at Peptides International.5) The CLEAR particles swell in a wide range of solvents including water, methylene chloride, or DMF. They are also compatible with relatively non-polar solvents such as THF or dioxane. Synthesis can be performed on CLEAR in automated or manual synthesizers. Many other uses are possible with this exciting new product: In organic synthesis. In affinity chromatography. In enzyme immobilization. In trace analysis. In remote sensor applications. CLEAR may be the resin to consider in your research.
- M. Kempe, G. Barany, “CLEAR: A Novel Family of Highly Cross-Linked Polymeric Supports for Solid Phase Peptide Synthesis,” J. Am. Chem. Soc., 118, 7083 (1996).
- M. Kempe, G. Barany, “Novel Highly Cross-Linked Supports for Solid Phase Applications,” in Solid Phase Synthesis (Fourth International Symposium, Edinburgh, Scotland), R. Epton, Ed., Mayflower (London) 1996 p.191.
- E. Bayer, M. Mutter, Natute (London), 237, 512 (1972).
- K.D. Janda, “Tagged Versus Untagged Libraries: Methods for Degeneration and Screening of Combinatorial Chemical Libraries,” Proc. Natl. Acad. Sci., USA, 91, 10779 (1994).
- K. Darlak, I. Romanovska, A. Spatola, G. Barany and M. Kempe, “A New Solid Support for Peptide and Organic Synthesis,” (Fifteenth American Peptide Symposium, Nashville, Tennessee USA).