List of Fluoro-/Chromogenic Substrates

MOCAc/Dnp type Substrates

Code Compound Target Protease
3216-v MOCAc-Ala-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(Dnp)-NH2 Proteinase A / Pepsin
3167-v MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 Matrix Metalloproteinases
3168-v MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 Matrix Metalloproteinase-3 (Stromelysin 1)
3184-v MOCAc-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-NH2 Caspase-3
3200-v MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 Cathepsin D/E
3225-v MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 Cathepsin E
3226-v MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 Matrix Metalloproteinase-1/2/3/7/8/9/13/14
Collagenase / Gelatinase / Matrilysin / Stromelysin
ADAM-17 / Tumor Necrosis Factor Converting Enzyme (TACE)
3163-v MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 Matrix Metalloproteinase
3164-s MOCAc-Pro-Leu-Gly Reference Compound for MOCAc-type Fluorescence-Quenching Substrate
3212-v MOCAc-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 β-Secretase
3183-v MOCAc-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-NH2 Caspase-1

Nma/Dnp type Substrates

Code Compound Target Protease
3224-s FRETS-VWF73 ADAMTS-13
3217-v Nma-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH2 γ-Secretase
3229-v Nma-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(Dnp)-D-Arg-D-Arg-NH2 Human Renin
3233-v Nma-Phe-His-Lys(Dnp) Angiotensin I Converting Enzyme and Carboxypeptidase Y
3237-v Nma-His-Pro-Lys(Dnp) Angiotensin I Converting Enzyme 2

Abz/EDDnp type Substrates

Code Compound Target Protease
3230-v Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Human Neutrophil Elastase
3231-v Abz-Glu-Pro-Phe-Trp-Glu-Asp-Gln-EDDnp Human Neutrophil Cathepsin G
3232-v Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp Human Neutrophil Proteinase 3

Dabcyl/Edans type Substrates

Code Compound Target Protease
3249-v Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu(Edans)-NH2 SARS-CoV/SARS-CoV-2 Main Protease (Mpro)

MCA-Substrates

Code Compound Target Protease
3250-v Ac-Abu-Tle-Leu-Gln-MCA SARS-CoV/SARS-CoV-2 Main Protease (Mpro)
3220-v Ac-Asp-Asn-Leu-Asp-MCA Caspase-3
3193-v Ac-Asp-Gln-Thr-Asp-MCA Caspase-7/3
3171-v Ac-Asp-Glu-Val-Asp-MCA Caspase-3/7/8
3227-v Ac-Glu-Ser-Glu-Asn-MCA Vacuolar Processing Enzyme (VPE)
3195-v Ac-Ile-Glu-Thr-Asp-MCA Caspase-8/6 and Granzyme B
3198-v Ac-Leu-Glu-His-Asp-MCA Caspase-9
3185-v Ac-Lys-Thr-Lys-Gln-Leu-Arg-MCA Hepatocyte Growth Factor-Activator (HGF-A)
3251-v Ac-Thz-Tle-Leu-Gln-MCA SARS-CoV/SARS-CoV-2 Main Protease (Mpro)
3186-v Ac-Trp-Glu-His-Asp-MCA Caspase-1/14
3161-v Ac-Tyr-Val-Ala-Asp-MCA Caspase-1
3203-v Ac-Val-Asp-Val-Ala-Asp-MCA Caspase-2
3181-v Ac-Val-Glu-Ile-Asp-MCA Caspase-6
3201-v Ala-Ala-Phe-MCA Tripeptidyl Peptidase II
3147-v Ala-MCA Aminopeptidase
3099-v AMC Reference Compound
3113-v Arg-MCA Cathepsin H
3144-v Boc-Ala-Gly-Pro-Arg-MCA rANP Precursor Processing Enzyme
3155-v Boc-Arg-Val-Arg-Arg-MCA Furin
3139-v Boc-Asp(OBzl)-Pro-Arg-MCA α-Thrombin
3135-v Boc-Gln-Ala-Arg-MCA Trypsin
3122-v Boc-Gln-Arg-Arg-MCA Carboxyl Side of Paired Basic Residue Cleaving Enzyme
3136-v Boc-Gln-Gly-Arg-MCA Factor XIIa
3115-v Boc-Glu(OBzl)-Gly-Arg-MCA
3134-v Boc-Glu(OBzl)-Ala-Arg-MCA Factor XIa
3105-v Boc-Glu-Lys-Lys-MCA Plasmin
3142-v Boc-Gly-Arg-Arg-MCA Carboxyl Side of Paired Basic Residue Cleaving Enzyme
3143-v Boc-Gly-Lys-Arg-MCA Carboxyl Side of Paired Basic Residue Cleaving Enzyme
3094-v Boc-Ile-Glu-Gly-Arg-MCA Factor Xa
3140-v Boc-Leu-Arg-Arg-MCA Carboxyl Side of Paired Basic Residue Cleaving Enzyme
3102-v Boc-Leu-Gly-Arg-MCA Horseshoe Crab Clotting Enzyme
3141-v Boc-Leu-Lys-Arg-MCA Carboxyl Side of Paired Basic Residue Cleaving Enzyme
3112-v Boc-Leu-Ser-Thr-Arg-MCA Activated Protein C
3106-v Boc-Leu-Thr-Arg-MCA Factor VIIa-Tf
3107-v Boc-Phe-Ser-Arg-MCA Trypsin, Tryptase, 73K Protease, and Arg-Gingipain
3104-v Boc-Val-Leu-Lys-MCA Plasmin and Calpain
3093-v Boc-Val-Pro-Arg-MCA α-Thrombin
3092-v Bz-Arg-MCA Trypsin
3154-v Glt-Ala-Ala-Phe-MCA Chymotrypsin
3097-v Glt-Gly-Arg-MCA u-PA (Urokinase)
3090-v Gly-Pro-MCA X-Prolyl Dipeptidyl-Aminopeptidase
3091-v Leu-MCA Aminopeptidase
3235-v Leu-Asp-MCA Porphyromonas Gingivalis Dipeptidyl-Peptidase 11
3124-v Lys-Ala-MCA Dipeptidyl-Aminopeptidase II
3132-v Lys-MCA Aminopeptidase
3149-v Met-MCA Aminopeptidase
3236-v Met-Leu-MCA Porphyromonas Gingivalis Dipeptidyl-Peptidase 7
3148-v Phe-MCA Aminopeptidase
3243-v Phe-Met-MCA Bacterial Dipeptidyl Peptidase-7
3096-v Pro-Phe-Arg-MCA Pancreatic/Urinary Kallikrein, and Proteasome
3159-v Pyr-Arg-Thr-Lys-Arg-MCA Furin
3145-v Pyr-Gly-Arg-MCA t-PA and u-PA (Urokinase)
3101-v Pyr-MCA Pyroglutamyl Peptidase
3153-v Suc(OMe)-Ala-Ala-Pro-Val-MCA Human Leukocyte/Porcine Pancreatic Elastase
3114-v Suc-Ala-Ala-Pro-Phe-MCA Chymotrypsin
3133-v Suc-Ala-Ala-Ala-MCA Elastase
3160-v Suc-Ala-Glu-MCA Ingensin and Proteasome
3100-v Suc-Ala-Pro-Ala-MCA Elastase
3110-v Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-MCA Renin and Proteinase A
3222-v Suc-D-Asp-MCA D-Aspartyl Endopeptidase
3108-v Suc-Gly-Pro-Leu-Gly-Pro-MCA Collagenase-like Peptidase
3109-v Suc-Gly-Pro-MCA Post-Proline Cleaving Enzyme, Prolyl Endopeptidase
3158-v Suc-Ile-Ala-MCA Amyloid A4 Generating Enzyme
3150-v Suc-Ile-Ile-Trp-MCA
3120-v Suc-Leu-Leu-Val-Tyr-MCA Chymotrypsin, Ingensin/Proteasome and Calpain
3209-v Z-Ala-Ala-Asn-MCA Legumain
3123-v Z-Arg-Arg-MCA Cathepsin B
3252-v Z-Arg-Leu-Arg-Gly-Gly-MCA Isopeptidase T and SARS-CoV/SARS-CoV-2 Papain-like Protease (PLpro)
3248-v Z-Gly-Gly-Arg-MCA Thrombin
3208-v Z-Gly-Pro-Arg-MCA Cathepsin K
3215-v Z-His-Glu-Lys-MCA Lys-Gingipain
3176-v Z-Leu-Arg-Gly-Gly-MCA Isopeptidase T
3210-v Z-Leu-Arg-MCA Cathepsin K/S/V
3177-v Z-Leu-Leu-Leu-MCA Proteasome
3179-v Z-Leu-Leu-Glu-MCA Proteasome
3095-v Z-Phe-Arg-MCA Plasma Kallikrein, Cathepsin B/L, and Arg-Gingipain
3138-v Z-Pyr-Gly-Arg-MCA Factor Xa
3156-v Z-Val-Lys-Met-MCA Amyloid A4-generating enzyme and Proteasome
3211-v Z-Val-Val-Arg-MCA Cathepsin S/L
3206-v Ubiquitin-MCA Deubiquitinating Enzyme
AH-397 D-CHA-Ala-Arg-MCA Thrombin

ACC-Substrate

Code Compound Target Protease
3240-v Ac-Lys-Val-Pro-Leu-ACC Granzyme M

pNA-Substrates

Code Compound Target Protease
3068 Ala-pNA Aminopeptidase
3125 Boc-Leu-Ser-Thr-Arg-pNA Activated Protein C
3013 Bz-DL-Arg-pNA.HCl Trypsin-like Protease
3057 Bz-L-Arg-pNA.HCl Trypsin-like Protease / Papain
3015 Bz-Tyr-pNA Chymotrypsin
3129 Glt-Ala-Ala-Pro-Leu-pNA Pancreatic Elastase
3066 Glu(pNA) γ-Glutamyl Transpeptidase
3067 Glu-pNA
3074-v Gly-Pro-pNA.Tos [GPNT]
 X-Prolyl Dipeptidyl-Aminopeptidase
3014 Leu-pNA Aminipeptidase
3130 Pyr-Phe-Leu-pNA Thiol Protease
3228-v Pyr-Pro-Val-pNA Human Granulocyte Elastase
3071 Suc-Ala-Ala-Ala-pNA Elastase
3071-v Suc-Ala-Ala-Ala-pNA Elastase
3117 Suc-Ala-Ala-pNA
3162-v Suc-Ala-Leu-Pro-Phe-pNA PPIase (Peptidyl Prolyl cis-trans Isomerase)
3116 Suc-Ala-pNA
3118 Suc-Ala-Pro-Ala-pNA Elastase
3127 Z-Ala-Ala-Leu-pNA Subtilisin A and Serine Protease of Bacillus subtilis IFO3027, Neprilysin
3111 Z-Gly-Gly-Leu-pNA Neutral Endopeptidase

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