ProTx-II

Code:
4450-s
Name:
ProTx-II
Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp (Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25)
(M.W. 3826.6) C168H250N46O41S8
Na+ Channel (Especially Nav1.7) / Ca2+ Channel Blocker (Gating Modifier)
Package Price(Yen) Availability Quantity  
Vial 0.1 mg 20,000 Ships within
1-3 business days
バルク見積もり

main

Purity:
≧97.0% (HPLC)
View Analytical Data Sheet
Other Name:
ProTx-2
プロトキシン-2
プロトキシン-II
Storage:
-20 ℃
Source:
Tarantula, Thrixopelma pruriens
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. R.E. Middleton, V.A. Warren, R.L. Kraus, J.C. Hwang, C.J. Liu, G. Dai, R.M. Brochu, M.G. Kohler, Y.-D. Gao, V.M. Garsky, M.J. Bogusky, J.T. Mehl, C.J. Cohen, and M.M. Smith, Biochemistry, 41, 14734 (2002). (Original)
  2. J.J. Smith, T.R. Cummins, S. Alphy, and K.M. Blumenthal, J. Biol. Chem., 282, 12687 (2007). (Pharmacol.; Novel Toxin Binding Site Coupled to Nav Activation)
  3. W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, A.B. Weinglass, G.J. Kaczorowski, M.L. Garcia, M. Koltzenburg, and B.T. Priest, Mol. Pharmacol,, 74, 1476 (2008). (Pharmacol.; Inhibition of Nav1.7 Channels)
  4. S.D. Dib-Hajj, T.R. Cummins, J.A. Black, and S.G. Waxman, Trends Neurosci., 30, 555 (2007). (Review)
  5. B.T. Priest, K.M. Blumenthal, J.J. Smith, V.A. Warren, and M.M. Smith, Toxicon, 49, 194 (2007). (Review)
  6. S. Sokolov, R.L. Kraus, T. Scheuer, and W.A. Catterall, Pharmacol., 73, 1020 (2008). (Pharmacol.)

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