4450-s ProTx-II

Code:
4450-s
Name:
ProTx-II
Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp (Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25)
(M.W. 3826.6) C168H250N46O41S8
Na+ Channel (Especially Nav1.7) / Ca2+ Channel Blocker (Gating Modifier)
Package Price(Yen)
Vial 0.1 mg 20,000

main

Purity:
≧97.0% (HPLC)
Other Name:
ProTx-2
プロトキシン-2
プロトキシン-II
Storage:
-20 ℃
Source:
Tarantula, Thrixopelma pruriens
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. R.E. Middleton, V.A. Warren, R.L. Kraus, J.C. Hwang, C.J. Liu, G. Dai, R.M. Brochu, M.G. Kohler, Y.-D. Gao, V.M. Garsky, M.J. Bogusky, J.T. Mehl, C.J. Cohen, and M.M. Smith, Biochemistry, 41, 14734 (2002). (Original)
  2. J.J. Smith, T.R. Cummins, S. Alphy, and K.M. Blumenthal, J. Biol. Chem., 282, 12687 (2007). (Pharmacol.; Novel Toxin Binding Site Coupled to Nav Activation)
  3. W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, A.B. Weinglass, G.J. Kaczorowski, M.L. Garcia, M. Koltzenburg, and B.T. Priest, Mol. Pharmacol,, 74, 1476 (2008). (Pharmacol.; Inhibition of Nav1.7 Channels)
  4. S.D. Dib-Hajj, T.R. Cummins, J.A. Black, and S.G. Waxman, Trends Neurosci., 30, 555 (2007). (Review)
  5. B.T. Priest, K.M. Blumenthal, J.J. Smith, V.A. Warren, and M.M. Smith, Toxicon, 49, 194 (2007). (Review)
  6. S. Sokolov, R.L. Kraus, T. Scheuer, and W.A. Catterall, Pharmacol., 73, 1020 (2008). (Pharmacol.)