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ProTx-II
- Code:
- 4450-s
- Name:
- ProTx-II
- Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp (Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25)
- (M.W. 3826.6) C168H250N46O41S8
- Na+ Channel (Especially Nav1.7) / Ca2+ Channel Blocker (Gating Modifier)
| Package | Price(Yen) | Availability |
|---|---|---|
| Vial 0.1 mg | 20,000 |
Ships within 1-3 business days |
| Bulk Request | ||
- main
- more information
- reference
main
- Purity:
- ≧97.0% (HPLC)
- View Analytical Data Sheet
- Other Name:
- ProTx-2
- プロトキシン-2
- プロトキシン-II
- Storage:
- -20 ℃
- Source:
- Tarantula, Thrixopelma pruriens
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- R.E. Middleton, V.A. Warren, R.L. Kraus, J.C. Hwang, C.J. Liu, G. Dai, R.M. Brochu, M.G. Kohler, Y.-D. Gao, V.M. Garsky, M.J. Bogusky, J.T. Mehl, C.J. Cohen, and M.M. Smith, Biochemistry, 41, 14734 (2002). (Original)
- J.J. Smith, T.R. Cummins, S. Alphy, and K.M. Blumenthal, J. Biol. Chem., 282, 12687 (2007). (Pharmacol.; Novel Toxin Binding Site Coupled to Nav Activation)
- W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, A.B. Weinglass, G.J. Kaczorowski, M.L. Garcia, M. Koltzenburg, and B.T. Priest, Mol. Pharmacol,, 74, 1476 (2008). (Pharmacol.; Inhibition of Nav1.7 Channels)
- S.D. Dib-Hajj, T.R. Cummins, J.A. Black, and S.G. Waxman, Trends Neurosci., 30, 555 (2007). (Review)
- B.T. Priest, K.M. Blumenthal, J.J. Smith, V.A. Warren, and M.M. Smith, Toxicon, 49, 194 (2007). (Review)
- S. Sokolov, R.L. Kraus, T. Scheuer, and W.A. Catterall, Pharmacol., 73, 1020 (2008). (Pharmacol.)
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