Epoxomicin
- Code:
- 4381-v
- Name:
- Epoxomicin
- (2R)-2-[Acetyl-(N-methyl-L-isoleucyl)-L-isoleucyl-L-threonyl-L-leucyl]-2-methyloxirane
- (M.W. 554.72) C28H50N4O7
- Inhibitor for Proteasome
- main
- more information
- reference
main
- Purity:
- ≧95.0% (HPLC)
- Other Name:
- エポキソミシン
- Storage:
- -20 ℃
- Production:
- Synthetic Product
Solubility: DMSO (1 mM)
more information
- Structure:
- Category:
- Enzyme Inhibitors
reference
- L. Meng, R. Mohan, B.H.B. Kwok, M. Elofsson, N. Sin, and C.M. Crews, Proc. Natl. Acad. Sci. USA, 96, 10403 (1999). (Proteasome Inhibitor & Antiinflammatory Activity)
- N. Sin, K.B. Kim, M. Elofsson, L. Meng, H. Auth, B.H.B. Kwok, and C.M. Crews, Bioorg. Med. Chem. Lett., 9, 2283 (1999). (Proteasome Inhibitor)
- K.B. Kim, J. Myung, N. Sin, and C.M. Crews, Bioorg. Med. Chem. Lett., 9, 3335 (1999). (Proteasome Inhibitor)
- M. Groll, K.B. Kim, N. Kairies, R. Huber, and C.M. Crews, J. Am.Chem. Soc., 122, 1237 (2000). (Crystal Structure of Proteasome Complex)
- D. Leung, G. Abbenante, and D.P. Fairlie, J. Med. Chem., 43, 305 (2000).
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