Epoxomicin

Code:
4381-v
Name:
Epoxomicin
(2R)-2-[Acetyl-(N-methyl-L-isoleucyl)-L-isoleucyl-L-threonyl-L-leucyl]-2-methyloxirane
(M.W. 554.72) C28H50N4O7
Inhibitor for Proteasome
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Vial 0.2 mg 20,000 Ships within
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Purity:
≧95.0% (HPLC)
Other Name:
エポキソミシン
Storage:
-20 ℃
Production:
Synthetic Product

Solubility: DMSO (1 mM)

more information

Structure:
structure of Epoxomicin
Category:
Enzyme Inhibitors

reference

  1. L. Meng, R. Mohan, B.H.B. Kwok, M. Elofsson, N. Sin, and C.M. Crews, Proc. Natl. Acad. Sci. USA, 96, 10403 (1999). (Proteasome Inhibitor & Antiinflammatory Activity)
  2. N. Sin, K.B. Kim, M. Elofsson, L. Meng, H. Auth, B.H.B. Kwok, and C.M. Crews, Bioorg. Med. Chem. Lett., 9, 2283 (1999). (Proteasome Inhibitor)
  3. K.B. Kim, J. Myung, N. Sin, and C.M. Crews, Bioorg. Med. Chem. Lett., 9, 3335 (1999). (Proteasome Inhibitor)
  4. M. Groll, K.B. Kim, N. Kairies, R. Huber, and C.M. Crews, J. Am.Chem. Soc., 122, 1237 (2000). (Crystal Structure of Proteasome Complex)
  5. D. Leung, G. Abbenante, and D.P. Fairlie, J. Med. Chem., 43, 305 (2000).

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