Deoxyfructosyl Peptides/Amino Acids 2019/02/07

Reducing sugars such as glucose are known to glycosylate proteins by non-enzymatic reaction with amino groups of proteins in vivo. The series of reactions is known as the Maillard reaction starting from Amadori rearrangement, and the modified compounds are called Amadori compounds and/or Maillard compounds. After oxidation and dehydration reaction, it leads to AGEs (Advanced Glycation End Products). AGEs typified by Pentosidine have been reported to affect age-related diseases.
　
Figure 1. Amadori rearrangement reaction of D-glucose and N-terminal Val residue of hemoglobin in vivo

Figure 1. Amadori rearrangement reaction of D-glucose with N-terminal Val residue of hemoglobin in vivo.

　
　
Glycosylated hemoglobin A1c (HbA1c) is an Amadori compound in which blood glucose is bound to the N-terminal Val residue of hemoglobin β chain. HbA1c is used as a diagnostic marker for diabetes, and its amount can be measured by the enzymatic method as shown in Figure 2.
　
Figure 2. Measurement of HbA1c by enzymatic method

Figure 2. Measurement of HbA1c by enzymatic method.

　
　
We have released several deoxyfructosyl products in small amount package size.
　
　

Code Product Quantity
24011-v 1-Deoxyfructosyl-Gly 1 mg vial
24012-v Lys(1-Deoxyfructosyl) 1 mg vial
24013-v 1-Deoxyfructosyl-Val [Fru-Val] 1 mg vial
24014-v 1-Deoxyfructosyl-Val-His [Fru-Val-His] 1 mg vial
24015-v 1-Deoxyfructosyl-Val-His-Leu-Thr-Pro-Glu 1 mg vial
3413-v Val-His-Leu-Thr-Pro-Glu 0.5 mg vial
3414-v Val-His-[D7]Leu-Thr-Pro-Glu 50 μg vial
3415-v 1-Deoxyfructosyl-Val-His-[D7]Leu-Thr-Pro-Glu 50 μg vial
3417-s Lys(1-Deoxyfructosyl[13C6]) 0.1 mg vial
3256-v Carboxymethyllysine 1 mg vial
24019-v 3-Deoxyglucosone 1 mg vial

　
　
Bulk supply as well as custom synthesis of different glycosylation reaction products such as 3-Deoxyglucosone (3-DG) / Carboxymethyl Lysine (CML), and AGEs are available on request. Please feel free to contact us.

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