Novel Cancer Imaging Probe; 2-NBDLG 2016/02/02

23003_en_2-NBDLG_Fig-1

2-NBDG (code 23002-v) has been widely utilized for monitoring D-glucose uptake in a variety of mammalian cells1). 2-NBDLG (code 23003-v), an antipode of 2-NBDG, was initially developed as the control substrate derived from L-glucose which is not used as major source of energy2, 3).
Surprisingly, 2-NBDLG uptake into spheroid-forming MIN6 insulinoma was found out by Yamada et al.4, 5). Moreover, Onoe et al. showed that a high contrast between a tumor cell (C6 glioma) and a normal one in tumor model mouse can be obtained by administration of 2-NBDLG4).
Imaging method using 2-NBDLG is expected as a new diagnostics of cancers.
　
　

Code Compound Quantity
23002-v 2-NBDG 0.5 mg vial
23003-v 2-NBDLG 0.5 mg vial

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  1. Nature Protocols, 2, 753 (2007). DOI: 10.1038/nprot.2007.76 (Protocols for Measurement)
  2. Tetrahedron Lett, 49, 6876 (2008). DOI: 10.1016/j.tetlet.2008.09.089 (Chem. Synthesis)
  3. Bioorg. Med. Chem. Lett, 21, 4088 (2011).
  4. Patent WO 2012133688 A1.
  5. Human Cell, 29, 37 (2016). DOI: 10.1007/s13577-015-0125-3

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