[Novel peptide identified using a genomic technology]
What is a pharmacological effect? What is a physiological role? Now you can study using this synthetic peptide.
The cDNAs of the μ-, δ-, and κ-opioid receptors have been cloned. ORL1, a novel member of the opioid receptor family, was cloned and its functional expression and localization have been reported.[FEBS Lett., 341, 33 (1994)]
Recently, the endogenous ligand of this orphan receptor has been reported by two groups. Nociceptin is isolated from rat brain [Nature,377, 532 (1995)], and orphanin FQ from porcine brain [Science, 270, 792 (1995)]. Nociceptin and orphanin FQ is a 17 amino-acid residue peptide with the same sequence. This peptide is identified using an inhibitory action of forskolin-stimulated cAMP accumulation in CHO cells.
Human and mouse nociceptin(orphanin FQ), with the same amino acid sequence have been reported. [Proc. Natl. Acad. Sci., 93, 8666 (1996); ibid., 93, 8677 (1996)]
Nociceptin induces both allodynia (pain resulting from a non-noxious stimulus to normal skin) and hyperalgesia when administered intrathecally. The ORL1 receptor transcripts are expressed in several areas of the central nervous system that are known to be involved in pain regulation and in modulating synaptic plasticity. In addition, precursor polypeptide resembles pro-opiomelanocortin, they may have stumbled upon a treasure trove of new bioactive peptides.[Nature, 377, 476 (1995)]
|4318-v||Nociceptin (Human)||0.5 mg vial||15,000|