APETx2
- Code:
- 4472-s
- Name:
- APETx2
- Gly-Thr-Ala-Cys-Ser-Cys-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys-Arg-Tyr-Phe-Leu-Gly-Thr-Cys-Cys-Thr-Pro-Ala-Asp (Reported disulfide bonds between Cys4-Cys37, Cys6-Cys30, Cys20-Cys38)
- (M.W. 4561.0) C196H280N54O61S6
- Selective Blocker of Acid-Sensing Ion Channel, ASIC3
- main
- more information
- reference
main
- Purity:
- ≧99.0% (HPLC)
- View Analytical Data Sheet
- Storage:
- -20 ℃
- Source:
- Sea Anemone, Anthopleura elegantissima
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- S. Diochot, A. Baron, L.D. Rash, E. Deval, P. Escoubas, S. Scarzello, M. Salinas, and M. Lazdunski, EMBO J., 23, 1516 (2004). (Original ; Primary Structure, S-S Bond & Pharmacol.)
- B. Chagot, P. Escoubas, S. Diochot, C. Bernard, M. Lazdunski, and H. Darbon, Protein Sci., 14, 2003 (2005). (NMR Structure)
- S. Diochot, M. Salinas, A. Baron, P. Escoubas, and M. Lazdunski, Toxicon, 49, 271 (2007). (Pharmacol.)
- E. Deval, J. Noël, N. Lay, A. Alloui, S. Diochot, V. Friend, M. Jodar, M. Lazdunski, and E. Lingueglia, EMBO J., 27, 3047 (2008). (Pharmacol.)
- J. Karczewski, R.H. Spencer, V.M. Garsky, A. Liang, M.D. Leitl, M.J. Cato, S.P. Cook, S. Kane and M.O. Urban, Br. J. Pharmacol., 16, 950 (2010). (Pharmacol.)
- E. Deval, J. Noël, X. Gasull, A. Delaunay, A. Alloui, V. Friend, A. Eschalier, M. Lazdunski, and E. Lingueglia, J. Neurosci., 31, 6059 (2011). (Pharmacol.)
- W.-L. Wu, C.-F. Cheng, W.-H. Sun, C.-W. Wong, and C.-C. Chen, Pharmacol. Ther., 134, 127 (2012). (Review; Pharmacol.)
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