APETx2

Documents

Gly-Thr-Ala-Cys-Ser-Cys-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys-Arg-Tyr-Phe-Leu-Gly-Thr-Cys-Cys-Thr-Pro-Ala-Asp (Reported disulfide bonds between Cys⁴-Cys³⁷, Cys⁶-Cys³⁰, Cys²⁰-Cys³⁸)
: (M.W. 4561.0) C₁₉₆H₂₈₀N₅₄O₆₁S₆
: Selective Blocker of Acid-Sensing Ion Channel, ASIC3

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Solubility: H₂O (0.1 mM)

S. Diochot, A. Baron, L.D. Rash, E. Deval, P. Escoubas, S. Scarzello, M. Salinas, and M. Lazdunski, EMBO J., 23, 1516 (2004). (Original ; Primary Structure, S-S Bond & Pharmacol.)
B. Chagot, P. Escoubas, S. Diochot, C. Bernard, M. Lazdunski, and H. Darbon, Protein Sci., 14, 2003 (2005). (NMR Structure)
S. Diochot, M. Salinas, A. Baron, P. Escoubas, and M. Lazdunski, Toxicon, 49, 271 (2007). (Pharmacol.)
E. Deval, J. Noël, N. Lay, A. Alloui, S. Diochot, V. Friend, M. Jodar, M. Lazdunski, and E. Lingueglia, EMBO J., 27, 3047 (2008). (Pharmacol.)
J. Karczewski, R.H. Spencer, V.M. Garsky, A. Liang, M.D. Leitl, M.J. Cato, S.P. Cook, S. Kane and M.O. Urban, Br. J. Pharmacol., 16, 950 (2010). (Pharmacol.)
E. Deval, J. Noël, X. Gasull, A. Delaunay, A. Alloui, V. Friend, A. Eschalier, M. Lazdunski, and E. Lingueglia, J. Neurosci., 31, 6059 (2011). (Pharmacol.)
W.-L. Wu, C.-F. Cheng, W.-H. Sun, C.-W. Wong, and C.-C. Chen, Pharmacol. Ther., 134, 127 (2012). (Review; Pharmacol.)

Data Sheet