Huwentoxin-IV
- Code:
- 4455-s
- Name:
- Huwentoxin-IV
- HWTX-IV
- Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Arg-Trp-Cys-Lys-Tyr-Gln-Ile-NH2 (Disulfide bonds between Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31)
- (Trifluoroacetate Form)
- (M.W. 4106.8) C174H278N52O51S6
- Neuronal Tetrodotoxin-Sensitive Na+-Channel Blocker
- main
- more information
- reference
main
- Purity:
- ≧97.0% (HPLC)
- Storage:
- -20 ℃
- Source:
- Chinese Bird Spider, Ornithoctonus huwena
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- K. Peng, Q. Shu, Z. Liu, and S. Liang, J. Biol. Chem., 277, 47564 (2002). (Original)
- J. Diao, Y. Lin, J. Tang, and S. Liang, Toxicon, 42, 715 (2003). (cDNA Seq)
- Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang, and T.R. Cummins, J. Biol. Chem., 283, 27300 (2008). (Pharmacol.)
- Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng, and S. Liang, Toxicon, 51, 230 (2008). (Pharmacol.)
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