μ-Conotoxin SIIIA
- Code:
- 4440-v
- Name:
- μ-Conotoxin SIIIA
- Pyr-Asn-Cys-Cys-Asn-Gly-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bonds between Cys3-Cys13, Cys4-Cys19, and Cys8-Cys20)
- (M.W. 2207.5) C83H123N33O27S6
- Na+ Channel Blocker with Analgesic Activity
- main
- more information
- reference
main
- Purity:
- ≧99.0% (HPLC)
- Storage:
- -20 ℃
- Source:
- Marine Snail, Conus striatus
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- G. Bulaj, P.J. West, J.E. Garrett, M. Marsh, M.-M. Zhang, R.S. Norton, B.J. Smith, D. Yoshikami, and B.M. Olivera, Biochemistry, 44, 7259 (2005). (Original; Primary Structure & Pharmacol.)
- S. Yao, M.-M. Zhang, D. Yoshikami, L. Azam, B.M. Olivera, G. Bulaj, and R.S. Norton, Biochemistry, 47, 10940 (2008). (Solution Structure, S-S Bond, & Pharmacol.)
- B.R. Green, P. Catlin, M.-M. Zhang, B. Fiedler, W. Bayudan, A. Morrison, R.S. Norton, B.J. Smith, D. Yoshikami, B.M. Olivera, and G. Bulaj, Chem. Biol., 14, 399 (2007). (Pharmacol.; Analgesic Activity)
- M.J. Wilson, D. Yoshikami, L. Azam, J. Gajewiak, B.M. Olivera, G. Bulaj, and M.M. Zhang, Proc. Natl. Acad. Sci. U.S.A., 108, 10302 (2011). (Pharmacol.; Survey of Tetrodotoxin-Sensitive Nav1 Isoforms)
- B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review)
- W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review)
- R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review)
- B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)
他の製品を検索する