μ-Conotoxin SIIIA

Code:
4440-v
Name:
μ-Conotoxin SIIIA
Pyr-Asn-Cys-Cys-Asn-Gly-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bonds between Cys3-Cys13, Cys4-Cys19, and Cys8-Cys20)
(M.W. 2207.5) C83H123N33O27S6
Na+ Channel Blocker with Analgesic Activity
Package Price(Yen) Availability
Vial 0.5 mg 30,000 Ships within
1-3 business days
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Purity:
≧99.0% (HPLC)
Storage:
-20 ℃
Source:
Marine Snail, Conus striatus
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. G. Bulaj, P.J. West, J.E. Garrett, M. Marsh, M.-M. Zhang, R.S. Norton, B.J. Smith, D. Yoshikami, and B.M. Olivera, Biochemistry, 44, 7259 (2005). (Original; Primary Structure & Pharmacol.)
  2. S. Yao, M.-M. Zhang, D. Yoshikami, L. Azam, B.M. Olivera, G. Bulaj, and R.S. Norton, Biochemistry, 47, 10940 (2008). (Solution Structure, S-S Bond, & Pharmacol.)
  3. B.R. Green, P. Catlin, M.-M. Zhang, B. Fiedler, W. Bayudan, A. Morrison, R.S. Norton, B.J. Smith, D. Yoshikami, B.M. Olivera, and G. Bulaj, Chem. Biol., 14, 399 (2007). (Pharmacol.; Analgesic Activity)
  4. M.J. Wilson, D. Yoshikami, L. Azam, J. Gajewiak, B.M. Olivera, G. Bulaj, and M.M. Zhang, Proc. Natl. Acad. Sci. U.S.A., 108, 10302 (2011). (Pharmacol.; Survey of Tetrodotoxin-Sensitive Nav1 Isoforms)
  5. B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review)
  6. W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review)
  7. R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review)
  8. B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)

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