Guangxitoxin-1E

Code:
4433-s
Name:
Guangxitoxin-1E
GxTX-1E
Glu-Gly-Glu-Cys-Gly-Gly-Phe-Trp-Trp-Lys-Cys-Gly-Ser-Gly-Lys-Pro-Ala-Cys-Cys-Pro-Lys-Tyr-Val-Cys-Ser-Pro-Lys-Trp-Gly-Leu-Cys-Asn-Phe-Pro-Met-Pro (Disulfide bonds between Cys4-Cys19, Cys11-Cys24, and Cys18-Cys31)
(Trifluoroacetate Form)
(M.W. 3948.6) C178H248N44O45S7
Kv2.1/Kv2.2 Channel Blocker / Enhancer of Glucose-Dependent Insulin Secretion
Package Price(Yen) Availability Quantity  
Vial 0.1 mg 22,000 Ships within
1-3 business days
バルク見積もり

main

Purity:
≧96.0% (HPLC)
View Analytical Data Sheet
Storage:
-20 ℃
Source:
Tarantula, Plesiophrictus guangxiensis sp. nov.
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. J. Herrington, Y.-P. Zhou, R.M. Bugianesi, P.M. Dulski, Y. Feng, V.A. Warren, M.M. Smith, M.G. Kohler, V.M. Garsky, M. Sanchez, M. Wagner, K. Raphaelli, P. Banerjee, C. Ahaghotu, D. Wunderler, B.T. Priest, J.T. Mehl, M.L. Garcia, O.B. McManus, G.J. K, Diabetes, 55, 1034 (2006). (Original)
  2. P.E. MacDonald, S. Sewing, J. Wang, J.W. Joseph, P.E. MacDonald, S. Sewing, J. Wang, J.W. Joseph, S.R. Smukler, G. Sakellaropoulos, J.Wang, M.C. Saleh, C.B. Chan,R.G. Tsushima, A.M.F. Salapatek, and M.B. Wheeler, J. Biol. Chem., 277, 44938 (2002). (Pharmacol.; Role of Kv2.1 in Glucose-Dependent Insulin Secretion)
  3. N.A. Tamarina, A. Kuznetsov, L.E. Fridlyand, and L.H. Philipson, Am. J. Physiol. Endocrinol. Metab., 289, E578 (2005). (Pharmacol.; Role of Kv2.1 in Glucose-Dependent Ca2+ response)
  4. J. Herrington, Toxicon, 49, 231 (2007). (Review)
  5. S. Lee, M. Milescu, H.H. Jung, J.Y. Lee, C.H. Bae, C.W. Lee, H.H. Kim, K.J. Swartz, and J.I. Kim, Biochemistry, 49, 5134 (2010). (Solution Structure & S-S Bond)

関連書類

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