GsMTx-4
- Code:
- 4393-s
- Name:
- GsMTx-4
- Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Disulfide bonds between Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30)
- (M.W. 4095.8) C185H273N49O45S6
- Inhibitor for Cation-Selective Stretch-Activated Channels / Atrial Fibrillation Inhibiting Peptide
- main
- more information
- reference
main
- Purity:
- ≧98.0% (HPLC)
- Storage:
- -20 ℃
- Source:
- Chilean Rose Tarantula, Grammostola spatulata
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- O.P. Hamill and B. Martinac, Physiol. Rev., 81, 685 (2001). (Review; MSCs)
- T.M. Suchyna, J.H. Johnson, K. Hamer, J.F. Leykam, D.A. Gage, H.F. Clemo, C.M. Baumgarten, and F. Sachs, J. Gen. Physiol., 115, 583 (2000). (Original)
- K.L. Ostrow, A. Mammoser, T. Suchyna, F. Sachs, R. Oswald, S. Kubo, N. Chino, and P.A. Gottlieb, Toxicon, 42, 263 (2003). (Primary structure; cDNA sequence & Pharmacol.)
- F. Bode, F. Sachs, and M.R. Franz, Nature, 409, 35 (2001). (Pharmacol.)
- R.E. Oswald, T.M. Suchyna, R. McFeeters, P. Gottlieb, and F. Sachs, J. Biol. Chem., 277, 34443 (2002). (Seq.; Correction of C-Terminal Sequence, S-S Bond)
- M.A. Spassova, T. Hewavitharana,W. Xu, J. Soboloff, and D.L. Gill, Proc. Natl. Acad. Sci. U.S.A., 103, 16586 (2006). (Pharmacol.)
- C.L. Bowman, P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy, and F. Sachs, Toxicon, 49, 249 (2007). (Review)
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