4393-s GsMTx-4

Code:
4393-s
Name:
GsMTx-4
Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Disulfide bonds between Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30)
(M.W. 4095.8) C185H273N49O45S6
Inhibitor for Cation-Selective Stretch-Activated Channels / Atrial Fibrillation Inhibiting Peptide
Package Price(Yen)
Vial 0.1 mg 24,000

main

Purity:
≧98.0% (HPLC)
Storage:
-20 ℃
Source:
Chilean Rose Tarantula, Grammostola spatulata
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. O.P. Hamill and B. Martinac, Physiol. Rev., 81, 685 (2001). (Review; MSCs)
  2. T.M. Suchyna, J.H. Johnson, K. Hamer, J.F. Leykam, D.A. Gage, H.F. Clemo, C.M. Baumgarten, and F. Sachs, J. Gen. Physiol., 115, 583 (2000). (Original)
  3. K.L. Ostrow, A. Mammoser, T. Suchyna, F. Sachs, R. Oswald, S. Kubo, N. Chino, and P.A. Gottlieb, Toxicon, 42, 263 (2003). (Primary structure; cDNA sequence & Pharmacol.)
  4. F. Bode, F. Sachs, and M.R. Franz, Nature, 409, 35 (2001). (Pharmacol.)
  5. R.E. Oswald, T.M. Suchyna, R. McFeeters, P. Gottlieb, and F. Sachs, J. Biol. Chem., 277, 34443 (2002). (Seq.; Correction of C-Terminal Sequence, S-S Bond)
  6. M.A. Spassova, T. Hewavitharana,W. Xu, J. Soboloff, and D.L. Gill, Proc. Natl. Acad. Sci. U.S.A., 103, 16586 (2006). (Pharmacol.)
  7. C.L. Bowman, P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy, and F. Sachs, Toxicon, 49, 249 (2007). (Review)