Chlorotoxin
- Code:
- 4282-v
- Name:
- Chlorotoxin
- Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2 (Reported disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33, and Cys20-Cys35)
- (M.W. 3995.7) C158H249N53O47S11
- Small-Conductance Cl- Channel Blocker
- main
- more information
- reference
main
- Purity:
- ≧96.0% (HPLC)
- Storage:
- -20 ℃
- Source:
- Scorpion, Leiurus quinquestriatus
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- J.A. DeBin, J.E. Maggio, and G.R. Strichartz, Am. J. Physiol., 264, C361 (1993). (Original)
- J. Najib, P. Sautiere, J.C. Gesquiere, and A. Tartar, Inovation and Perspective in Solid Phase Synthesis, (R. Epton, ed.), Mayflower Worldwide, Birmingham, pp. 615-618 (1994). (Original; Amide)
- G. Lippens, J. Najib, S.J. Wodak, and A. Tartar, Biochemistry, 34, 13 (1995). (NMR Structure)
- L. Soroceanu, Y. Gillespie, M.B. Khazaeli, and H. Sontheimer, Cancer Res., 58, 4871 (1998). (Pharmacol.)
- D.B. Jacoby, E. Dyskin, M. Yalcin, K. Kesavan, W. Dahlberg, J. Ratliff, E.W. Johnson, and S.A. Mousa, Anticancer Res., 30, 39 (2010). (Review)
- K. Kesavan, J. Ratliff, E.W. Johnson, W. Dahlberg, J.M. Asara, P. Misra, J.V. Frangioni, and D.B. Jacoby, J. Biol. Chem., 285, 4366 (2010). (Review)
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