4282-v Chlorotoxin

Code:
4282-v
Name:
Chlorotoxin
Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2 (Reported disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33, and Cys20-Cys35)
(M.W. 3995.7) C158H249N53O47S11
Small-Conductance Cl- Channel Blocker
Package Price(Yen)
Vial 0.5 mg 45,000

main

Purity:
≧96.0% (HPLC)
Storage:
-20 ℃
Source:
Scorpion, Leiurus quinquestriatus
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

CAS Registry Number:
163515-35-3
Category:
Biologically Active Peptides

reference

  1. J.A. DeBin, J.E. Maggio, and G.R. Strichartz, Am. J. Physiol., 264, C361 (1993). (Original)
  2. J. Najib, P. Sautiere, J.C. Gesquiere, and A. Tartar, Inovation and Perspective in Solid Phase Synthesis, (R. Epton, ed.), Mayflower Worldwide, Birmingham, pp. 615-618 (1994). (Original; Amide)
  3. G. Lippens, J. Najib, S.J. Wodak, and A. Tartar, Biochemistry, 34, 13 (1995). (NMR Structure)
  4. L. Soroceanu, Y. Gillespie, M.B. Khazaeli, and H. Sontheimer, Cancer Res., 58, 4871 (1998). (Pharmacol.)
  5. D.B. Jacoby, E. Dyskin, M. Yalcin, K. Kesavan, W. Dahlberg, J. Ratliff, E.W. Johnson, and S.A. Mousa, Anticancer Res., 30, 39 (2010). (Review)
  6. K. Kesavan, J. Ratliff, E.W. Johnson, W. Dahlberg, J.M. Asara, P. Misra, J.V. Frangioni, and D.B. Jacoby, J. Biol. Chem., 285, 4366 (2010). (Review)