(3,5-Difluorophenylacetyl)-Ala-Phg-OBut

Code:
3219-v
Name:
(3,5-Difluorophenylacetyl)-Ala-Phg-OBut
DAPT
(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine t-butyl ester
(M.W. 432.46) C23H26N2O4F2
Inhibitor for γ-Secretase
Package Price(Yen) Availability Quantity  
Vial 5 mg 10,000 Ships within
1-3 business days

main

Purity:
≧99.0% (HPLC)
View Analytical Data Sheet
Storage:
-20 ℃
Production:
Synthetic Product

Solubility: DMSO (10 mM)

more information

Structure:
構造図(3,5-Difluorophenylacetyl)-Ala-Phg-OBut
Category:
Enzyme Inhibitors

reference

  1. H.F. Dovey, V. John, J.P. Anderson, L.Z. Chen, P. de Saint Andrieu, L.Y. Fang, S.B. Freedman, B. Folmer, E. Goldbach, E.J. Holsztynska, K.L. Hu, K.L. Johnson-Wood, S.L. Kennedy, D. Kholodenko, J.E. Knops, L.H. Latimer, M. Lee, Z. Liao, I.M. Lieberburg, R.N. Motter, L.C. Mutter, J. Nietz, K.P. Quinn, K.L. Sacchi, P.A. Seubert, G.M. Shopp, E.D. Thorsett, J.S. Tung, J. Wu, S. Yang, C.T. Yin, D.B. Schenk, P.C. May, L.D. Altstiel, M.H. Bender, L.N. Boggs, T.C. Britton, J.C. Clemens, D.L. Czilli, D.K. Dieckman-McGinty, J.J. Droste, K.S. Fuson, B.D. Gitter, P.A. Hyslop, E.M. Johnstone, W-Y. Li, S.P. Little, T.E. Mabry, F.D. Miller, B. Ni, J.S. Nissen, W.J. Porter, B.D. Potts, J.K. Reel, D. Stephenson, Y. Su, L.A. Shipley, C.A. Whitesitt, T. Yin, and J.E. Audia, J. Neurochem., 76, 173 (2001). (Original; Functional γ -Secretase Inhibitor in Brain)
  2. A.Y. Kornilova, C. Das, and M.S. Wolfe, J. Biol. Chem., 278, 16470 (2003). (Comparison of in Cells and Cell-Free Activity)
  3. D. Leung, G. Abbenante, and D.P. Fairlie, J. Med. Chem., 43, 305 (2000).

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