Fluorescent Trapping Agents for Reactive Metabolites Detection: CysGlu-Dan, Dap-Dan 2023/08/07

CysGlu-Dan and Dap-Dan, fluorescent trapping agents developed by Professor Tomoyuki Ohe at Keio University, make it possible to detect and quantify a wide range of reactive metabolites1),2).

CysGlu-Dan is capable of efficiently detecting metabolites such as aldehydes that were not detectable using traditional trapping agent, dGSH (Dansyl-GSH), thus expanding the range of target reactive metabolites1).
　
　
CysGlu-Dan_Scheme
　
　
Dap-Dan allows for the detection and quantification of acyl glucuronides, metabolites of drugs containing carboxyl groups. Dap-Dan detects such metabolites much more efficiently than traditional trapping agent dansyl-lysine-phenylalanine dipeptide (dKF)2).
　
　
DapGlu-Dan_Scheme
　
　

Code Product Name Quant
3430-v Dap-Dan 2 mg
3431-v CysGlu-Dan 2 mg
3411 Dns-Glu(Cys-Gly) 10 mg

　
　For bulk quantities, please contact us.
　
　

  1. C. Shibazaki, T. Ohe, K. Takahashi, S. Nakamura, and T. Mashino, Drug Metab. Pharmacokinet., 39, 100386 (2021).
  2. C. Shibazaki, O. Mashita, K. Takahashi, S. Nakamura, T. Mashino, and T. Ohe, Chem. Res. Toxicol., 34, 2343 (2021).

    3. 　

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