L-685,458

Code:
4394-v
Name:
L-685,458
[(2R,4R,5S)-2-Benzyl-5-(t-butyloxycarbonylamino)-4-hydroxy-6-phenylhexanoyl]-L-leucyl-L-phenylalanine amide
(M.W. 672.85) C39H52N4O6
Inhibitor for γ-Secretase
Package Price(Yen) Availability Quantity  
Vial 1 mg 30,000 Ships within
1-3 business days

main

Brochures:
4394_L-685_458_jp.pdf
Purity:
≧99.0% (HPLC)
Other Name:
Boc-F-psi[CHOH-CH2]-FFLF-NH2
Storage:
-20 ℃
Production:
Synthetic Product

Solubility: DMSO (1 mM)

more information

Structure:
構造図L-685,458
Category:
Enzyme Inhibitors

reference

  1. Y.-M. Li, M. Xu, M.-T. Lai, Q. Huang, J.L. Castro, J. DiMuzio-Mower, T. Harrison, C. Lellis, A. Nadin, J.G. Neduvelil, R.B. Register, M.K. Sardana, M.S. Shearman, A.L. Smith, X.-P. Shi, K.-C. Yin, J.A. Shafer, and S.J. Gardell, Nature, 405, 689 (2000). (Biochem.; γ -Secretase Inhibitor)
  2. Y.-M. Li, M.-T. Lai, M. Xu, Q. Huang, J. DiMuzio-Mower, M.K. Sardana, X.-P. Shi, K.-C. Yin, J.A. Shafer, and S.J. Gardell, Proc. Natl. Acad. Sci. U.S.A., 97, 6138 (2000). (Biochem.; γ -Secretase Inhibitor)
  3. M.S. Shearman, D. Beher, E.E. Clarke, H.D. Lewis, T. Harrison, P. Hunt, A. Nadin, A.L. Smith, G. Stevenson, and J.L. Castro, Biochemistry, 39, 8698 (2000). (Biochem.; γ -Secretase Inhibitor)
  4. G.Tian, C.D. Sobotka-Briner, J. Zysk, X. Liu, C. Birr, M.A. Sylvester, P.D. Edwards, C.D. Scott, and B.D. Greenberg, J. Biol. Chem., 277, 31499 (2002). (Biochem.; Inhibition Mechanism)
  5. D. Leung, G. Abbenante, and D.P. Fairlie, J. Med. Chem., 43, 305 (2000).

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