L-685,458
- Code:
- 4394-v
- Name:
- L-685,458
- [(2R,4R,5S)-2-Benzyl-5-(t-butyloxycarbonylamino)-4-hydroxy-6-phenylhexanoyl]-L-leucyl-L-phenylalanine amide
- (M.W. 672.85) C39H52N4O6
- Inhibitor for γ-Secretase
- main
- more information
- reference
main
- Purity:
- ≧99.0% (HPLC)
- Other Name:
- Boc-F-psi[CHOH-CH2]-FFLF-NH2
- Storage:
- -20 ℃
- Production:
- Synthetic Product
Solubility: DMSO (1 mM)
more information
- Structure:
- Category:
- Enzyme Inhibitors
reference
- Y.-M. Li, M. Xu, M.-T. Lai, Q. Huang, J.L. Castro, J. DiMuzio-Mower, T. Harrison, C. Lellis, A. Nadin, J.G. Neduvelil, R.B. Register, M.K. Sardana, M.S. Shearman, A.L. Smith, X.-P. Shi, K.-C. Yin, J.A. Shafer, and S.J. Gardell, Nature, 405, 689 (2000). (Biochem.; γ -Secretase Inhibitor)
- Y.-M. Li, M.-T. Lai, M. Xu, Q. Huang, J. DiMuzio-Mower, M.K. Sardana, X.-P. Shi, K.-C. Yin, J.A. Shafer, and S.J. Gardell, Proc. Natl. Acad. Sci. U.S.A., 97, 6138 (2000). (Biochem.; γ -Secretase Inhibitor)
- M.S. Shearman, D. Beher, E.E. Clarke, H.D. Lewis, T. Harrison, P. Hunt, A. Nadin, A.L. Smith, G. Stevenson, and J.L. Castro, Biochemistry, 39, 8698 (2000). (Biochem.; γ -Secretase Inhibitor)
- G.Tian, C.D. Sobotka-Briner, J. Zysk, X. Liu, C. Birr, M.A. Sylvester, P.D. Edwards, C.D. Scott, and B.D. Greenberg, J. Biol. Chem., 277, 31499 (2002). (Biochem.; Inhibition Mechanism)
- D. Leung, G. Abbenante, and D.P. Fairlie, J. Med. Chem., 43, 305 (2000).
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