α-Conotoxin ImI
- Code:
- 4311-v
- Name:
- α-Conotoxin ImI
- Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Disulfide bonds between Cys2-Cys8 and Cys3-Cys12)
- (M.W. 1351.6) C52H78N20O15S4
- Blocker for Nicotinic Acetylcholine Receptor in Central Nervous System
- main
- more information
- reference
main
- Purity:
- ≧99.0% (HPLC)
- Storage:
- -20 ℃
- Source:
- Marine Snail, Conus imperialis
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- J.M. McIntosh, D. Yoshikami, E. Mahe, D.B. Nielsen, J.E. Rivier, W.R. Gray, and B.M. Olivera, J. Biol. Chem., 269, 16733 (1994). (Original)
- D.S. Johnson, J. Martinez, A.B. Elgoyhen, S.F. Heinemann, and J.M. McIntosh, Mol. Pharmacol., 48, 194 (1995). (Pharmacol.)
- E.F.R. Pereira, M. Alkondon, J.M. McIntosh, and E.X. Albuquerque, J. Pharmacol. Exp. Ther., 278, 1472 (1996). (Pharmacol.; Competitive Antagonist)
- B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review)
- W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review)
- R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review)
- B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)
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