D-GsMTx-4

Documents

Gly-D-Cys-D-Leu-D-Glu-D-Phe-D-Trp-D-Trp-D-Lys-D-Cys-D-Asn-D-Pro-D-Asn-D-Asp-D-Asp-D-Lys-D-Cys-D-Cys-D-Arg-D-Pro-D-Lys-D-Leu-D-Lys-D-Cys-D-Ser-D-Lys-D-Leu-D-Phe-D-Lys-D-Leu-D-Cys-D-Asn-D-Phe-D-Ser-D-Phe-NH2
: (M.W. 4095.8) C₁₈₅H₂₇₃N₄₉O₄₅S₆
: Inhibitor of Mechanosensitive Ion Channels (e.g. Piezo2)

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Solubility: H₂O (0.1 mM)

T.M. Suchyna, S.E. Tape, R.E.II Koeppe, O.S. Andersen, F. Sachs, and P.A. Gottlieb, Nature, 430, 235 (2004). (Original)
C.L. Bowman, P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy, and F. Sachs, Toxicon, 49, 249 (2007). (Review)
C. Bae, F. Sachs, and P.A. Gottlieb, Biochemistry, 50, 6295 (2011). (Piezo1 Channel Inhibitor)
R. Gnanasambandam, C. Ghatak, A. Yasmann, K. Nishizawa, F. Sachs, A.S. Ladokhin, S.I. Sukharev, and T.M. Suchyna, Biophys. J., 112, 31 (2017). (Mechanism Study of Inhibiting Mechanosensitive Ion Channels)
C. Alcaino, K. Knutson, P.A. Gottlieb, G. Farrugia, and A. Beyder, Channels, 11, 245 (2017). (Piezo2 Channel Inhibitor)
M.M. Maneshi, L. Ziegler, F. Sachs, S.Z. Hua, and P.A. Gottlieb, Sci. Rep., 8, 14267 (2018).

Data Sheet