Dendrotoxin I

Documents

Pyr-Pro-Leu-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asp-Pro-Gly-Arg-Cys-Tyr-Gln-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Gly-Phe-Thr-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Arg-Lys (Disulfide bonds between Cys⁷-Cys⁵⁷, Cys¹⁶-Cys⁴⁰, and Cys³²-Cys⁵³)
: (M.W. 7133.2) C₃₁₂H₄₈₇N₉₇O₈₄S₆
: Voltage-dependent K⁺ Channel Blocker

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Solubility: 0.1% AcOH (10 μM)

D.J. Strydom, Nature New Biol., 243, 88 (1973). (Original)
J.-N. Bidard, C. Mourre, and M. Lazdunski, Biochem. Biophys. Res. Commun., 143, 383 (1987). (Pharmacol.)
A.L. Harvey, D.L. Marshall, F.A. De-Allie, and P.N. Strong, Biochem. Biophys. Res. Commun., 163, 394 (1989). (Pharmacol.)
H. Nishio, T. Inui, Y. Nishiuchi, C.L.C. De Medeiros, E.G. Rowan, A.L. Harvey, E. Katoh, T. Yamazaki, T. Kimura, and S. Sakakibara, J. Pept. Res., 51, 355 (1998). (Chem. Synthesis & Correction of Sequence; Asp¹²)

Data Sheet