α-Defensin-6 (Human)

Code:
4458-s
Name:
α-Defensin-6 (Human)
[HD-6 (Human Defensin-6)]
Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu (Disulfide bonds between Cys4-Cys31, Cys6-Cys20, and Cys10-Cys30)
(M.W. 3708.2) C156H228N46O46S7
Antimicrobial Peptide in Paneth Cells
Package Price(Yen) Availability
Vial 0.1 mg 22,000 Ships within
1-3 business days

main

Purity:
≧98.0% (HPLC)
View Analytical Data Sheet
Other Name:
α-ディフェンシン-6
α-デフェンシン-6
Storage:
-20 ℃
Production:
Synthetic Product

more information

Category:
Biologically Active Peptides

reference

  1. D.E. Jones and C.L. Bevins, FEBS Lett., 315, 187 (1993). (Original;mRNA Seq.)
  2. E.M. Porter, M.A. Poles, J.S. Lee, J. Naitoh, C.L. Bevins, and T. Ganz, FEBS Lett., 434, 272 (1998). (Endogenous Form)
  3. B. Ericksen, Z. Wu, W. Lu, and R.I. Lehrer, Antimicrob. Agents Chemother., 49, 269 (2005). (Pharmacol.; No Antibacterial Activity)
  4. J. Wehkamp, K. Schmidt, K.R. Herrlinger, S. Baxmann, S. Behling, C. Wohlschläger, A.C. Feller, E.F. Stange, and K. Fellermann, J. Clin. Pathol., 56, 352 (2003). (Pharmacol.; Enhanced Expression in Helicobacter pylori Infection)
  5. E. Hazrati, B. Galen, W. Lu, W. Wang, Y. Ouyang, M.J. Keller, R.I. Lehrer. and B.C. Herold, J. Immunol., 177, 8658 (2006). (Pharmacol.; Inhibition of Herpes Simplex Virus Infection)
  6. M. Doss, M.R. White, T. Tecle, D. Gantz, E.C. Crouch, G. Jung, P. Ruchala, A.J. Waring, R.I. Lehrer, and K.L. Hartshorn, J. Immunol., 182, 7878 (2009). (Pharmacol.; Influenza A Virus Neutralizing Activity)
  7. M.J. Koslowski, J. Beisner, E.F. Stange, and J. Wehkamp, Int. J. Med. Microbiol., 300, 34 (2010). (Minireview; Antimicrobial Host Defense in Small Crohn's Disease)
  8. M.E. Klotman, A. Rapista, N. Teleshova, A. Micsenyi, G.A. Jarvis, W. Lu, E. Porter, and T.L. Chang, J. Immunol., 180, 6176 (2008). (Pharmacol.; Enhancement of HIV Infectivity)
  9. R.I. Lehrer and T. Ganz, Ann. N. Y. Acad. Sci., 797, 228 (1996). (Review)
  10. M. Zasloff, Nature, 415, 389 (2002). (Review)
  11. T. Hirsch, F. Jacobsen, H.-U. Steinau, and L. Steinstraesser, Protein Pept. Lett., 15, 238 (2008). (Review)
  12. M. Pazgier, X. Li, W. Lu, and J. Lubkowski, Curr. Pharm. Des., 13, 3096 (2007). (Review)
  13. Y. Lai and R.L. Gallo, Trends Immunol., 30, 131 (2009). (Review)

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