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Psalmotoxin 1
- Code:
- 4435-s
- Name:
- Psalmotoxin 1
- PcTX1
- Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr (Disulfide bonds between Cys3-Cys18, Cys10-Cys23, and Cys17-Cys33)
- (Trifluoroacetate Form)
- (M.W. 4689.4) C200H312N62O57S6
- Selective Blocker for Acid-Sensitive Ion Channel, ASIC1a
| Package | Price(Yen) | Availability |
|---|---|---|
| Vial 0.1 mg | 23,000 |
Ships within 1-3 business days |
| Bulk Request | ||
- main
- more information
- reference
main
- Purity:
- ≧97.0% (HPLC)
- Storage:
- -20 ℃
- Source:
- South American Tarantula, Psalmopoeus cambridgei
- Production:
- Synthetic Product
Solubility: H2O (0.1 mM)
more information
- Category:
- Biologically Active Peptides
reference
- P. Escoubas, J.R. De Weille, A. Lecoq, S. Diochot, R. Waldmann, G. Champigny, D. Moinier, A. Ménez, and M. Lazdunski, J. Biol. Chem., 275, 25116 (2000). (Original; Primary Structure & ASIC Blocking Selectivity)
- P. Escoubas, C. Bernard, G. Lambeau, M. Lazdunski, and H. Darbon, Protein Sci., 12, 1332 (2003). (Three-dimensional Solution Structure)
- X. Chen, H. Kalbacher, and S. Gründer, J. Gen. Physiol., 127, 267 (2006). (Pharmacol.; State-Dependent Function)
- X. Chen, H. Kalbacher, and S. Gründer, J. Gen. Physiol., 126, 71 (2005). (Pharmacol.; Mechanism of Channel Inhibition)
- J.K. Bubien, H.-L. Ji, G.Y. Gillespie, C.M. Fuller, J.M. Markert, T.B. Mapstone, and D.J. Benos, Am. J. Physiol., 287, C1282 (2004). (Pharmacol.; Inhibition of Malignant Glioma Na+ Channels)
- Z.-G. Xiong, X.-M. Zhu, X.-P. Chu, M. Minami, J. Hey, W.-L. Wei, J.F. MacDonald, J.A. Wemmie, M.P. Price, M.J. Welsh, and R.P. Simon, Cell, 118, 687 (2004). (Pharmacol.; Neuroprotection in Ischemia)
- S. Diochot, M. Salinas, A. Baron, P. Escoubas, and M. Lazdunski, Toxicon, 49, 271 (2007). (Review)
- Y.J. Qadri, B.K. Berdiev, Y. Song, H.L. Lippton, C.M. Fuller, and D.J. Benos, J. Biol. Chem., 284, 17625 (2009). (Pharmacol.)
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