Margatoxin

Code:
4290-s
Name:
Margatoxin
MgTX
Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Reported disulfide bonds between Cys7-Cys29, Cys13-Cys34, and Cys17-Cys36)
(M.W. 4178.9) C178H286N52O50S7
Voltage-Dependent K+ Channel Blocker (Specific for Kv1.3 Channel )
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Purity:
≧98.0% (HPLC)
Storage:
-20 ℃
Source:
Scorpion, Centruroides margaritatus
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. R.J. Leonard, M.L. Garcia, R.S. Slaughter, and J.P. Reuben, Proc. Natl. Acad. Sci. USA, 89, 10094 (1992). (Pharmacol.)
  2. M. Garcia-Calvo, R.J. Leonard, J. Novick, S.P. Stevens, W. Schmalhofer, G.J. Kaczorowski, and M.L. Garcia, J. Biol. Chem., 268, 18866 (1993). (Original)
  3. M.A. Bednarek, R.M. Bugianesti, R.J. Leonard, and J.P. Felix, Biochem. Biophys. Res. Commun., 198, 619 (1994). (Chem. Synthesis & S-S Bond)
  4. H.G. Knaus, R.O.A. Koch, A. Eberhart, G.J. Kaczorowski, M.L. Garcia, and R.S. Slaughter, Biochemistry, 34, 13627 (1995). (Pharmacol.)

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