{"id":4872,"date":"2023-08-07T10:20:05","date_gmt":"2023-08-07T01:20:05","guid":{"rendered":"https:\/\/www.peptide.co.jp\/en\/?p=4872"},"modified":"2023-09-07T13:35:40","modified_gmt":"2023-09-07T04:35:40","slug":"6915","status":"publish","type":"post","link":"https:\/\/www.peptide.co.jp\/en\/new-product\/6915.html","title":{"rendered":"Fluorescent Trapping Agents for Reactive Metabolites Detection: CysGlu-Dan, Dap-Dan"},"content":{"rendered":"<p>CysGlu-Dan and Dap-Dan, fluorescent trapping agents developed by Professor Tomoyuki Ohe at Keio University, make it possible to detect and quantify a wide range of reactive metabolites<sup>1),2)<\/sup>.<\/p>\n<p>CysGlu-Dan is capable of efficiently detecting metabolites such as aldehydes that were not detectable using traditional trapping agent, dGSH (Dansyl-GSH), thus expanding the range of target reactive metabolites<sup>1)<\/sup>.<br \/>\n\u3000<br \/>\n\u3000<br \/>\n<img loading=\"lazy\" class=\"aligncenter size-full wp-image-4070\" src=\"https:\/\/www.peptide.co.jp\/public_html\/wp-content\/uploads\/2023\/07\/3430_3431-8.jpg\" alt=\"CysGlu-Dan_Scheme\" width=\"766\" height=\"190\" \/><br \/>\n\u3000<br \/>\n\u3000<br \/>\nDap-Dan allows for the detection and quantification of acyl glucuronides, metabolites of drugs containing carboxyl groups. Dap-Dan detects such metabolites much more efficiently than traditional trapping agent dansyl-lysine-phenylalanine dipeptide (dKF)<sup>2)<\/sup>.<br \/>\n\u3000<br \/>\n\u3000<br \/>\n<img loading=\"lazy\" class=\"aligncenter size-full wp-image-4070\" src=\"https:\/\/www.peptide.co.jp\/public_html\/wp-content\/uploads\/2023\/07\/3430_3431-9.jpg\" alt=\"DapGlu-Dan_Scheme\" width=\"770\" height=\"364\" \/><br \/>\n\u3000<br \/>\n\u3000<\/p>\n<table style=\"width: 90%;margin-top:30px\" border=\"1\">\n<tbody>\n<tr>\n<td align=\"center\">Code<\/td>\n<td align=\"center\">Product Name<\/td>\n<td align=\"center\">Quant<\/td>\n<\/tr>\n<tr>\n<td align=\"center\"><a href=\"\/catalog\/f-cat?k_code=3430-v\">3430-v<\/a><\/td>\n<td align=\"center\">Dap-Dan<\/td>\n<td align=\"center\">2 mg<\/td>\n<\/tr>\n<tr>\n<td align=\"center\"><a href=\"\/catalog\/f-cat?k_code=3431-v\">3431-v<\/a><\/td>\n<td align=\"center\">CysGlu-Dan<\/td>\n<td align=\"center\">2 mg<\/td>\n<\/tr>\n<tr>\n<td align=\"center\"><a href=\"\/catalog\/f-cat?k_code=3411\">3411<\/a><\/td>\n<td align=\"center\">Dns-Glu(Cys-Gly)<\/td>\n<td align=\"center\">10 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u3000<br \/>\n\u3000For bulk quantities, <a href=\"https:\/\/www.peptide.co.jp\/en\/support\/inquiry\">please contact us.<\/a><br \/>\n\u3000<br \/>\n\u3000<\/p>\n<hr \/>\n<ol class=\"ref\">\n<li>C. Shibazaki, T. Ohe, K. Takahashi, S. Nakamura, and T. Mashino, <i>Drug Metab. Pharmacokinet<\/i>., <b>39<\/b>, 100386 (2021).<\/li>\n<li>C. Shibazaki, O. Mashita, K. Takahashi, S. Nakamura, T. Mashino, and T. Ohe, <i>Chem. Res. Toxicol<\/i>., <b>34<\/b>, 2343 (2021).<\/li>\n<p>\u3000<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CysGlu-Dan and Dap-Dan, fluorescent trapping agents developed by Professor Tomoyuki Ohe at Keio University, ma [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/4872"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=4872"}],"version-history":[{"count":10,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/4872\/revisions"}],"predecessor-version":[{"id":4980,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/4872\/revisions\/4980"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=4872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=4872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=4872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}