![\"rut-ii\"](\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/07\/rut-ii.gif\")
predicted precursor sequence and confirmed to possess potent vasoconstricting activity, as well as hypotensive activity. However, nothing has been reported since then concerning the endogenous form of rat UII.<\/p>\nRecently, Sugo and cowerkers of Takeda Chemical Industries, Ltd. have reported the discovery of an endogenous peptide in rat brain[Biochem. Biophys. Res. Commun.,<\/i> 310<\/b>, 860 (2003)], which was detected using an antibody against goby UII. Actually, they identified sole immunoreactivity in a single entity and the determined primary structure resembled that of UII. Therefore, they termed this newly identified peptide, urotensin II-related peptide<\/a> (URP). This newly discovered URP shows: i)<\/b> a saturable binding activity to human and rat UII receptors (UIIRs) with high affinity (Kd = 170 pM and 91 pM, respectively), ii)<\/b> a Ca2+<\/sup> mobilization activity in the Chinese hamster overy cells expressing human or rat UIIR with ED50<\/sub> values of 4.8 nM (human UIIR) and 0.55 nM (rat UIIR), and iii)<\/b> long-lasting hypotensive effect in anesthetized rat at 10 nmol\/kg dosage levels. Even though tissue levels of prepro-URP were found to be abundant in both human and rat, the distribution is different in both and also distinct from that of UII.<\/p>\n Now, that the endogenous form of rat UII peptide “urotensin II-related peptide” has been clarified, this should allow for more precise experiments concerning the biological activities elicited by the UII family of peptides.<\/p>\n Related Products<\/p>\n Endogeneous Ligand for Urotensin II-Receptor in Rat<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/479"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=479"}],"version-history":[{"count":1,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/479\/revisions"}],"predecessor-version":[{"id":4938,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/479\/revisions\/4938"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"uii-rp\"](\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/07\/uii-rp.gif\")
The cDNA sequence of rat URP was then determined, showing that this peptide sequence is flanked by the potential processing site, Lys-Arg, at its amino-terminus. Applying these same procedures, human and mouse URPs were also elucidated and determined to be identical to rat URP.<\/p>\n\n\n
\n Code<\/td>\n Compound<\/td>\n Package<\/td>\n<\/tr>\n \n 4408-v<\/a><\/td>\n Urotensin II-Related Peptide (Human, Rat)<\/td>\n 0.5 mg vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n Code<\/td>\n Compound<\/td>\n Package<\/td>\n<\/tr>\n \n 4365-v<\/a><\/td>\n Urotensin II (Human)<\/td>\n 0.5 mg vial<\/td>\n<\/tr>\n \n 4371-v<\/a><\/td>\n Urotensin II (Rat)<\/td>\n 0.5 mg vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"