{"id":3720,"date":"2019-02-07T15:56:53","date_gmt":"2019-02-07T06:56:53","guid":{"rendered":"https:\/\/www.peptide.co.jp\/en\/?p=3720"},"modified":"2024-11-20T16:38:54","modified_gmt":"2024-11-20T07:38:54","slug":"3919","status":"publish","type":"post","link":"https:\/\/www.peptide.co.jp\/en\/new-product\/3919.html","title":{"rendered":"Deoxyfructosyl Peptides\/Amino Acids"},"content":{"rendered":"

Reducing sugars such as glucose are known to glycosylate proteins by non-enzymatic reaction with amino groups of proteins in vivo<\/i>. The series of reactions is known as the Maillard reaction starting from Amadori rearrangement, and the modified compounds are called Amadori compounds and\/or Maillard compounds. After oxidation and dehydration reaction, it leads to AGEs (Advanced Glycation End Products). AGEs typified by Pentosidine<\/a> have been reported to affect age-related diseases.
\n\u3000
\n\"Figure<\/p>\n

Figure 1. Amadori rearrangement reaction of D-glucose with N<\/i>-terminal Val residue of hemoglobin in vivo<\/i>.<\/div>\n

\u3000
\n\u3000
\nGlycosylated hemoglobin A1c (HbA1c) is an Amadori compound in which blood glucose is bound to the N<\/i>-terminal Val residue of hemoglobin \u03b2 chain. HbA1c is used as a diagnostic marker for diabetes, and its amount can be measured by the enzymatic method as shown in Figure 2.
\n\u3000
\n\"Figure<\/p>\n

Figure 2. Measurement of HbA1c by enzymatic method.<\/div>\n

\u3000
\n\u3000
\nWe have released several deoxyfructosyl products in small amount package size.
\n\u3000
\n\u3000<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Code<\/td>\nProduct<\/td>\nQuantity<\/td>\n<\/tr>\n
24011-v<\/a><\/td>\n1-Deoxyfructosyl-Gly<\/td>\n1 mg vial<\/td>\n<\/tr>\n
24012-v<\/a><\/td>\nLys(1-Deoxyfructosyl)<\/td>\n1 mg vial<\/td>\n<\/tr>\n
24013-v<\/a><\/td>\n1-Deoxyfructosyl-Val [Fru-Val]<\/td>\n1 mg vial<\/td>\n<\/tr>\n
24014-v<\/a><\/td>\n1-Deoxyfructosyl-Val-His [Fru-Val-His]<\/td>\n1 mg vial<\/td>\n<\/tr>\n
24015-v<\/a><\/td>\n1-Deoxyfructosyl-Val-His-Leu-Thr-Pro-Glu<\/td>\n1 mg vial<\/td>\n<\/tr>\n
3413-v<\/a><\/td>\nVal-His-Leu-Thr-Pro-Glu<\/td>\n0.5 mg vial<\/td>\n<\/tr>\n
3417-s<\/a><\/td>\nLys(1-Deoxyfructosyl[13<\/sup>C6<\/sub>])<\/td>\n0.1 mg vial<\/td>\n<\/tr>\n
3256-v<\/a><\/td>\nCarboxymethyllysine<\/td>\n1 mg vial<\/td>\n<\/tr>\n
24019-v<\/a><\/td>\n3-Deoxyglucosone<\/td>\n1 mg vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u3000
\n\u3000
\nBulk supply as well as custom synthesis of different glycosylation reaction products such as 3-Deoxyglucosone (3-DG) \/ Carboxymethyl Lysine (CML), and AGEs are available on request. Please feel free to contact us.<\/a><\/p>\n

\n","protected":false},"excerpt":{"rendered":"

Reducing sugars such as glucose are known to glycosylate proteins by non-enzymatic reaction with amino groups […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/3720"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=3720"}],"version-history":[{"count":16,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/3720\/revisions"}],"predecessor-version":[{"id":5649,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/3720\/revisions\/5649"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=3720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=3720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=3720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}