{"id":313,"date":"2013-07-19T16:19:53","date_gmt":"2013-07-19T07:19:53","guid":{"rendered":"http:\/\/120.29.164.89\/?p=313"},"modified":"2023-08-29T11:05:35","modified_gmt":"2023-08-29T02:05:35","slug":"313","status":"publish","type":"post","link":"https:\/\/www.peptide.co.jp\/en\/new-product\/313.html","title":{"rendered":"Amyloid \u03b2-Protein (Human, 1-40) [HCl Form]"},"content":{"rendered":"<p><b>HCl Form of Amyloid \u03b2-Protein (Human, 1-40)<br \/>\nEasily Convertible to \u03b2-Structure! Now available!!<\/b><\/p>\n<p>Amyloid \u03b2-proteins (A\u03b2s) have been found as major plaque components in the brains of Alzheimer&#8217;s disease patients. Recently, Kaneko <i>et al.<\/i>reported that the HCl form of A\u03b2(1-40) takes \u03b2-structure within a few hours, and it shows neurotoxic activity. On the other hand, TFA salt takes &gt;1 week to take on a \u03b2-structure under their experimental conditions [<i>J. Neurochem.,<\/i><b>65<\/b>, 2585 (1995), <i>ibid.,<\/i><b>68<\/b>, 438 (1997)].<\/p>\n<p>We prepared the HCl form of A\u03b2(1-40) following their procedure and confirmed their observations shown above.<\/p>\n<p>Characteristics of our new product <a href=\"\/en\/catalog\/f-cat?k_code=4379-v\">A\u03b2(1-40) [HCl form]<\/a> are as follows; 1) random coil when supplied, 2) conformational change to \u03b2-structure within 24 hours (by CD measurement under our conditions), and 3) significant neurotoxic activity under our determining conditions. For more detail, please contact us.<\/p>\n<p>To perform the reproducible study in Alzheimer&#8217;s disease research, we now offer A\u03b2(1-40) [HCl Form] with the highest quality.<br \/>\n\u3000<\/p>\n<table style=\"width: 90%\" border=\"1\">\n<tbody>\n<tr>\n<td align=\"center\">Code<\/td>\n<td align=\"center\">Compound<\/td>\n<td align=\"center\">Quantity<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/en\/catalog\/f-cat?k_code=4379-v\">4379-v<\/a><\/td>\n<td>Amyloid \u03b2- Protein (Human, 1- 40) [HCl Form]<\/td>\n<td align=\"center\">0.5 mg vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\n\u3000<\/p>\n<div align=\"right\"><a href=\"https:\/\/www.peptide.co.jp\/en\/support\/useful\/amyloid-beta-protein\">View Other Related Products<\/a><\/div>\n<p>\n\u3000<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Easily Convertible to b-Structure!<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/313"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=313"}],"version-history":[{"count":4,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/313\/revisions"}],"predecessor-version":[{"id":4955,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/313\/revisions\/4955"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}