{"id":312,"date":"2013-07-19T16:19:09","date_gmt":"2013-07-19T07:19:09","guid":{"rendered":"http:\/\/120.29.164.89\/?p=312"},"modified":"2023-08-29T11:07:12","modified_gmt":"2023-08-29T02:07:12","slug":"312","status":"publish","type":"post","link":"https:\/\/www.peptide.co.jp\/en\/new-product\/312.html","title":{"rendered":"Urotensin II (Rat)"},"content":{"rendered":"

[Potent Vasoconstrictor]<\/b><\/p>\n

Urotensin II (U-II) is a disulfide-linked small peptide initially isolated from fish urophysis. Subsequently, the cDNA sequence encoding the human U-II precursor was determined, and the corresponding mRNA was found to exist predominantly in spinal cord [Proc. Natl. Acad. Sci. USA<\/i>, 95<\/b>, 15803 (1998)]. Human U-II, then, was revealed to be an agonist for the orphan receptor GPR14 and exerts a strong vasoconstricting activity in the isolated thoracic\"hut-ii\" aorta of rat [Nature<\/i>, 401<\/b>, 282 (1999)]. The potency of vasoconstriction of U-II is an order of magnitude greater than that of endothelin-1, making human U-II the most potent mammalian vasoconstrictor identified so far.<\/p>\n

Following the sequence determination of human U-II, the same group reported the corresponding rat peptide cDNA sequence [FEBS Lett<\/i>., 457<\/b>, 28 (1999)]. When we look at the deduced peptide sequence of rat prepro-U-II, there are two double basic sites at its C-terminal region, which might be the enzymatic cleavage sites for yielding the mature peptide of rat U-II. We chose the shorter peptide of 14 amino acid residues with pyroglutamic acid modification for Gln110<\/sup> as the possible candidate for rat U-II and chemically synthesized it. Synthetic [Pyr110<\/sup>]-prepro-U-II (110-123) was confirmed to have a vasoconstricting activity as potent as that of human peptide in the isolated thoracic aorta of rat (unpublished result). Therefore, \"rut-ii\"we tentatively named this peptide rat U-II in our catalog, although the mature form of rat U-II remains to be determined. Recently, Davenport AP & Maguire JJ have predicted the sequence of rat or mouse U-II as prepro-U-II (110-123) [Trends Pharmacol. Sci.<\/i>, 21<\/b>, 80 (2000)].<\/p>\n\n\n\n\n
Code<\/td>\nCompound<\/td>\nQuantity<\/td>\n<\/tr>\n
4371-v<\/a><\/td>\nUrotensin II (Rat)<\/td>\n0.5 mg vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n
Code<\/td>\nCompound<\/td>\nQuantity<\/td>\n<\/tr>\n
4365-v<\/a><\/td>\nUrotensin II (Human)<\/td>\n0.5 mg vial<\/td>\n<\/tr>\n
14365-v<\/a><\/td>\nUrotensin II (Human) Antiserum<\/td>\n0.05 ml vial<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
4327-s<\/a><\/td>\nUrocortin (Rat)<\/td>\n0.1 mg vial<\/td>\n<\/tr>\n
4328-s<\/a><\/td>\nUrocortin (Human)<\/td>\n0.1 mg vial<\/td>\n<\/tr>\n
4111-s<\/a><\/td>\nCRF (Ovine)<\/td>\n0.1 mg vial<\/td>\n<\/tr>\n
4136-s<\/a><\/td>\nCRF (Human, Rat)<\/td>\n0.1 mg vial<\/td>\n<\/tr>\n
14136-v<\/a><\/td>\nCRF (Human) Antiserum<\/td>\n0.05 ml vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Potent Vasoconstrictor<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/312"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=312"}],"version-history":[{"count":2,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/312\/revisions"}],"predecessor-version":[{"id":4957,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/312\/revisions\/4957"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}