![\"ghrelin-h-r\"](\"\/wp-content\/uploads\/2013\/07\/ghrelin-h-r.gif\")
<\/p>\n[Endogenous Growth-Hormone Releasing Peptide with Novel Regulatory Mechanism]<\/b><\/p>\n
Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from pituitary through a G-protein-coupled receptor (GHS-R) [Science<\/i>, 260<\/b>, 1640 (1993); Cell. Mol. Life Sci<\/i>., 54<\/b>, 1316 (1998)]. However, the specific endogenous ligand for this receptor has long been unidentified, therefore, this receptor is considered to be one of the orphan receptors. ]<\/p>\n
<\/p>\n
Endogenous ligand for GHS-R is now identified as ghrelin with the following characteristics: 1) ghrelin is a 28-residue peptide with a n-octanoyl group at Ser3<\/sup>, 2) ghrelin stimulates GH-release from rat primary cultured pituitary cells in a dose-dependent manner (EC50<\/sub> = 2.1 nM), and 3) ghrelin induces an increase of intracellular Ca2+<\/sup> in GHS-R-expressing cells with EC50<\/sub> value of 2.5 nM [Nature<\/i>, 402<\/b>, 656(1999)]. Although ghrelin and the known hypothalamic peptide, growth-hormone releasing factor, stimulate GH-release, there is distinction between these peptides both in GH secretion mechanism and in structural aspect. Octanoyl group attached on the side chain of Ser3<\/sup> is essential for expressing activity. Rat and human peptide sequences are clarified to be mutually identical except for the amino acid substitutions at positions 11 and 12. Interestingly, major ghrelin-producing tissue is the stomach, and ghrelin immunoreactivity is found in healthy human blood. This fact may provide the new regulation mechanism for GH-release; ghrelin secreted from the stomach circulates in the blood stream to the pituitary where this peptide exerts a GH-releasing function. It is conceivable that ghrelin may have other functions in some tissues other than pituitary, because GHS-R is expressed in heart, lung, pancreas, intestine and adipose tissue.<\/p>\n Endogenous Growth-Hormone Releasing Peptide with Novel Regulatory Mechanism<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/311"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=311"}],"version-history":[{"count":1,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/311\/revisions"}],"predecessor-version":[{"id":4958,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/311\/revisions\/4958"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n\n
\n Code<\/td>\n Compound<\/td>\n Package<\/td>\n<\/tr>\n \n 4372-s<\/a><\/td>\n Ghrelin (Human)<\/td>\n 0.1 mg vial<\/td>\n<\/tr>\n \n 4373-s<\/a><\/td>\n Ghrelin (Rat)<\/td>\n 0.1 mg vial<\/td>\n<\/tr>\n \n 4127-s<\/a><\/td>\n GRF (Human)<\/td>\n 0.1 mg Vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"