{"id":23,"date":"2013-07-07T22:57:40","date_gmt":"2013-07-07T13:57:40","guid":{"rendered":"http:\/\/120.29.164.89\/?p=23"},"modified":"2015-10-15T17:21:25","modified_gmt":"2015-10-15T08:21:25","slug":"23","status":"publish","type":"post","link":"https:\/\/www.peptide.co.jp\/en\/new-product\/23.html","title":{"rendered":"CLEAR RESINS"},"content":{"rendered":"<p>CLEAR resins (Cross-Linked Ethoxylate Acrylate Resins) were developed by George Barany and Maria Kempe at the University of Minnesota.<sup>1,2)<\/sup>\u00a0These products retain the highly desirable solvation properties of polyethylene glycol (PEG) and PEG-linked products but can be handled with infinitely greater convenience. Unlike conventional liquid phase synthesis, developed by Bayer and Mutter in the 1970s<sup>3)<\/sup>\u00a0and recently popularized by Janda in combinatorial synthesis<sup>4)<\/sup>, CLEAR resins are highly cross-linked. They are produced in a bead form employing a large-scale suspension polymerization process developed at Peptides International.<sup>5)<\/sup>\u00a0The CLEAR particles swell in a wide range of solvents including water, methylene chloride, or DMF. They are also compatible with relatively non-polar solvents such as THF or dioxane. Synthesis can be performed on CLEAR in automated or manual synthesizers. Many other uses are possible with this exciting new product: In organic synthesis. In affinity chromatography. In enzyme immobilization. In trace analysis. In remote sensor applications. CLEAR may be the resin to consider in your research.<\/p>\n<h4>References<\/h4>\n<ol class=\"ref\">\n<li>M. Kempe, G. Barany, &#8220;CLEAR: A Novel Family of Highly Cross-Linked Polymeric Supports for Solid Phase Peptide Synthesis,&#8221;\u00a0<i>J. Am. Chem. Soc.,<\/i>\u00a0<b>118,<\/b>\u00a07083 (1996).<\/li>\n<li>M. Kempe, G. Barany, &#8220;Novel Highly Cross-Linked Supports for Solid Phase Applications,&#8221; in Solid Phase Synthesis (Fourth International Symposium, Edinburgh, Scotland), R. Epton, Ed., Mayflower (London) 1996 p.191.<\/li>\n<li>E. Bayer, M. Mutter,\u00a0<i>Natute (London),<\/i>\u00a0<b>237,<\/b>\u00a0512 (1972).<\/li>\n<li>K.D. Janda, &#8220;Tagged Versus Untagged Libraries: Methods for Degeneration and Screening of Combinatorial Chemical Libraries,&#8221;\u00a0<i>Proc. Natl. Acad. Sci., USA,<\/i>\u00a0<b>91,<\/b>\u00a010779 (1994).<\/li>\n<li>K. Darlak, I. Romanovska, A. Spatola, G. Barany and M. Kempe, &#8220;A New Solid Support for Peptide and Organic Synthesis,&#8221; (Fifteenth American Peptide Symposium, Nashville, Tennessee USA).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>CLEAR resins (Cross-Linked Ethoxylate Acrylate Resins) were developed by George Barany and Maria Kempe at the  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/23"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":1,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/23\/revisions"}],"predecessor-version":[{"id":3388,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/23\/revisions\/3388"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=23"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=23"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}