{"id":118,"date":"2013-07-09T15:47:21","date_gmt":"2013-07-09T06:47:21","guid":{"rendered":"http:\/\/120.29.164.89\/?p=118"},"modified":"2023-08-29T11:11:01","modified_gmt":"2023-08-29T02:11:01","slug":"118","status":"publish","type":"post","link":"https:\/\/www.peptide.co.jp\/en\/new-product\/118.html","title":{"rendered":"Endomorphin \u2013 Endogenous agonist for \u03bc-opioid receptor"},"content":{"rendered":"

[The discovery and isolation of a potent and selective agonist for the \u03bc- opiate receptor from brain]<\/b><\/p>\n


\nMore than three opioid-receptor subtypes, termed \u03bc, \u03b4, \u03ba have been reported. The endogenous ligand for \u03b4 -receptor is enkephalin, and that for \u03ba -receptor is dynorphin. Although opiate alkaloids morphine is well-known for the \u03bc-selective and potent ligand, endogenous ligand “endogenous morphine” has never reported.<\/p>\n

Recently, endogenous agonists for the \u03bc-opiate receptor, were first isolated from bovine brain[Nature<\/i>, 386<\/b>, 499 (1997)]. These are endomorphin-1; Tyr-Pro-Trp-Phe-NH2<\/sub>, and endomorphin-2; Tyr-Pro-Phe-Phe-NH2<\/sub>. The isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex has also reported[Peptides<\/i>, 18<\/b>, 1635 (1997)].<\/p>\n

The immunoreactivity for endomorphin was also detected in rat brain near the \u03bc-opiate receptor containing neurons, but the molecular form of the rat peptide has not yet been elucidated[Peptides<\/i>, 18<\/b>, 1641 (1997)]. These observations may be considered to indicate that endomorphin-1 and 2 are common \u03bc-opiate agonists in mammals. In addition to the originally discovered \u03bc-opiate agonistic function, these peptides have been reported to show hypotensive activity and Ca2+<\/sup> channel current inhibitory activity[Biochem. Biophys. Res. Commun.<\/i>, 235<\/b>, 567 (1997)]. Endomorphins would be useful for the study of pain perception together with some other biological functions in the body.<\/p>\n

\"endmrphn\"<\/p>\n\n\n\n\n\n
Code<\/td>\nCompound<\/td>\nPackage<\/td>\n<\/tr>\n
4333-v<\/a><\/td>\nEndomorphin-1<\/td>\n0.5 mg vial<\/td>\n<\/tr>\n
4334-v<\/a><\/td>\nEndomorphin-2<\/td>\n0.5 mg vial<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

The discovery and isolation of a potent and selective agonist for the m-opiate receptor from brain<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/118"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=118"}],"version-history":[{"count":2,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/118\/revisions"}],"predecessor-version":[{"id":4966,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/posts\/118\/revisions\/4966"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/categories?post=118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/tags?post=118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}