{"id":73,"date":"2013-07-09T14:24:09","date_gmt":"2013-07-09T05:24:09","guid":{"rendered":"http:\/\/120.29.164.89\/?page_id=73"},"modified":"2016-01-06T15:07:14","modified_gmt":"2016-01-06T06:07:14","slug":"glycopeptides","status":"publish","type":"page","link":"https:\/\/www.peptide.co.jp\/en\/custom\/peptide_synthesis\/glycopeptides","title":{"rendered":"Glycopeptides"},"content":{"rendered":"<p class=\"catchphrase\" style=\"text-align: left\">In the synthesis of the glycosylated compounds such as glycopeptides and Maillard reaction products, a high level of carbohydrate chemistry knowledge and experience are vital to success. Our experts in both carbohydrate and peptide chemistries work together in the Saito Research Center, making the synthesis of any such compounds feasible.<br \/>\nPlease contact us soon even if the structure of your compound is not listed below.<\/p>\n<h3>Glycopeptides containing monosaccharides<\/h3>\n<p>Ser\/Thr(GlcNAc), Ser\/Thr(GalNAc), Asn(GlcNAc), Ser(Xyl), Thr(Man), etc<\/p>\n<div class=\"floatbox span1-3\">\n<p><img loading=\"lazy\" class=\"aligncenter\" alt=\"O-GlcNAc\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/08\/207-1.gif\" width=\"138\" height=\"98\" \/><\/p>\n<div class=\"textbox\">R=H : Ser(GlcNAc)<br \/>\nR=CH<sub>3<\/sub>: Thr(GlcNAc)<br \/>\n<span class=\"blue\">O-GlcNAcylation*<\/span><\/div>\n<\/div>\n<div class=\"floatbox span1-3\">\n<p><img loading=\"lazy\" class=\"aligncenter\" alt=\"Glycopeptides containing monosaccharides\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/08\/207-2.gif\" width=\"112\" height=\"131\" \/><\/p>\n<div class=\"textbox\">R=H : Ser(GalNAc)<br \/>\nR=CH<sub>3<\/sub>: Thr(GalNAc)<\/div>\n<\/div>\n<div class=\"floatbox span1-3\"><img loading=\"lazy\" class=\"aligncenter\" alt=\"Glycopeptides containing monosaccharides\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/08\/207-3.gif\" width=\"138\" height=\"118\" \/>Asn(GlcNAc)<\/div>\n<div class=\"boxstyle2\">\n<h4>*O-GlcNAcylation<\/h4>\n<p>O-GlcNAcylation is one of the posttranslational modifications of intracellular and nuclear proteins. This modification by GlcNAc is known to occur in over one thousand proteins and regulated dynamically by metabolic pathway in the similar way to protein phosphorylation. Protein O-GlcNAcylation has been shown to happen cooperatively with or competitively to protein phosphorylation, implying that O-GlcNAcylation possesses the function in the modulation of cellular signaling and transcriptional regulation. It has also been suggested that O-GlcNAcylation has some roles in diabetes and aging.<\/p>\n<p class=\"ref\">Hart,G.W. et al. Annu.Rev.Biochem. <b>80<\/b>, 825 (2011).<\/p>\n<\/div>\n<h3>Glycopeptides containing oligosaccharides<\/h3>\n<p>Ser\/Thr(Gal-GalNAc), Ser\/Thr(Neu-Gal-GalNAc), Asn(Fuc-GlcNAc), etc<\/p>\n<div class=\"floatbox span1-1\">\n<p>e.g.) Code <a href=\"https:\/\/www.peptide.co.jp\/en\/catalog\/f-cat?k_code=24007-v\">24007-v<\/a> Antiproliferative Factor Sialoglycopeptide (APF Sialoglycopeptide)<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter\" alt=\"24007-v\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/08\/207-4.gif\" width=\"482\" height=\"157\" \/><\/p>\n<\/div>\n<h3>AGEs (advanced glycation end products) (Maillard reaction products)<\/h3>\n<p>Deoxyfructosylation, pentosidine<\/p>\n<div class=\"floatbox span1-3\"><img loading=\"lazy\" class=\"aligncenter\" alt=\"1-Deoxyfructosyl-Val\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/08\/207-5.gif\" width=\"157\" height=\"108\" \/>1-Deoxyfructosyl-Val<br \/>\n(HbA1c)<\/div>\n<div class=\"floatbox span1-3\"><img loading=\"lazy\" class=\"aligncenter\" alt=\"Lys\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2013\/08\/207-6.gif\" width=\"224\" height=\"126\" \/>Lys(1-Deoxyfructosyl\uff09<\/div>\n<div class=\"floatbox span1-3\"><img loading=\"lazy\" class=\"aligncenter\" alt=\"pentosidine\" src=\"https:\/\/www.peptide.co.jp\/en\/wp-content\/uploads\/2016\/01\/pentosidine.gif\" width=\"224\" height=\"100\" \/><\/p>\n<div class=\"textbox\">\u3000<br \/>\npentosidine<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>In the synthesis of the glycosylated compounds such as glycopeptides and Maillard reaction products, a high le [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":999,"parent":65,"menu_order":3407,"comment_status":"open","ping_status":"closed","template":"page-custom.php","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/73"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=73"}],"version-history":[{"count":3,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/73\/revisions"}],"predecessor-version":[{"id":3468,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/73\/revisions\/3468"}],"up":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/65"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media\/999"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=73"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}