{"id":70,"date":"2013-07-09T14:21:28","date_gmt":"2013-07-09T05:21:28","guid":{"rendered":"http:\/\/120.29.164.89\/?page_id=70"},"modified":"2015-10-17T16:09:07","modified_gmt":"2015-10-17T07:09:07","slug":"cyclic_branched-peptides","status":"publish","type":"page","link":"https:\/\/www.peptide.co.jp\/en\/custom\/peptide_synthesis\/cyclic_branched-peptides","title":{"rendered":"Cyclic Peptides and Branched Peptides"},"content":{"rendered":"

Constraints by cyclization at either the backbone or side chain of the peptide are expected to reinforce and enhance the stability of the 3D-structure, such as \u03b1-helix, as well as the increment of the resistance to the enzymatic digestion.<\/p>\n

Cyclized Peptides<\/h3>\n
\n
\n

cyclo(X1<\/sub>-X2<\/sub>——–Xn<\/sub>)
\nHead-to-tail cyclization<\/h4>\n

\"cyclo(X1-X2--------Xn)<\/p>\n

X = NH : polypeptide
\nX = O : depsipeptide
\ne.g.) Code 4464-v<\/a> [D-Leu7<\/sup>]-(-)-Ternatin
\n(including N-methyl amino acids)<\/div>\n<\/div>\n
\n

Diketopiperazine
\n <\/h4>\n
\n

\"Diketopiperazine\"<\/p>\n

R=H : cyclo(X-Pro)
\nR=OH : cyclo(X-Hyp)<\/div>\n<\/div>\n
\n

\"Diketopiperazine\"<\/p>\n

cyclo(X-X)<\/div>\n<\/div>\n<\/div>\n
\n

Staple peptide<\/h4>\n

\"Staple<\/p>\n

site-specific ligation using olefin metathesis<\/div>\n<\/div>\n
\n

Cyclization at side chain<\/h4>\n

\"Cyclization<\/p>\n<\/div>\n

\n

Lactone\/Thiolactone<\/h4>\n

\"Lactone\/Thiolactone\"<\/p>\n

X=O : lactone
\nX=S : thiolactone<\/div>\n<\/div>\n
\n

Thioether<\/h4>\n

\"Thioether\"<\/p>\n<\/div>\n

\n

Deamino-dicarba<\/h4>\n
\"Deamino-dicarba\"<\/div>\n
\n
e.g.\uff09 Code 4025-v<\/a>
\n[Asu 1,6<\/sup>]-Oxytocin<\/span>
\n(Deamino-Dicarba-Oxytocin)<\/span><\/p>\n

 <\/p>\n

Code 4084-v<\/a> Oxytocin<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Branched Peptides\uff08Isopeptides\uff09<\/h3>\n
\n

Branched at Asp\/Glu<\/h4>\n

\"Branched<\/p>\n

n=1 : Asp
\nn=2 : Glu<\/div>\n<\/div>\n
\n

Branched at Lys<\/h4>\n

\"Branched<\/p>\n<\/div>\n

\n

Branched at Ser\/Thr<\/h4>\n

\"Branched<\/p>\n

X=H : Ser
\nX=CH3<\/sub> : Thr<\/div>\n<\/div>\n

We have lots of successful syntheses of the cyclic peptides as well as the branched peptides.
\nPlease contact us at the department of custom services when you intend to modify your peptide by cyclization or branching.<\/p>\n","protected":false},"excerpt":{"rendered":"

Constraints by cyclization at either the backbone or side chain of the peptide are expected to reinforce and e […]<\/p>\n","protected":false},"author":1,"featured_media":999,"parent":65,"menu_order":3404,"comment_status":"open","ping_status":"closed","template":"page-custom.php","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/70"}],"collection":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/comments?post=70"}],"version-history":[{"count":3,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/70\/revisions"}],"predecessor-version":[{"id":3398,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/70\/revisions\/3398"}],"up":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/pages\/65"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media\/999"}],"wp:attachment":[{"href":"https:\/\/www.peptide.co.jp\/en\/wp-json\/wp\/v2\/media?parent=70"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}