4428-s α-Defensin-2 (Human)

Code:
4428-s
Name:
α-Defensin-2 (Human)
HNP-2 (Human Neutrophil Peptide-2)
Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys (Disulfide bonds between Cys1-Cys29, Cys3-Cys18, and Cys8-Cys28)
(M.W. 3371.0) C147H217N43O37S6
Antimicrobial Peptide
Package Price(Yen)
Vial 0.1 mg 20,000

main

Purity:
≧99.0% (HPLC)
Other Name:
α-ディフェンシン-2
α-デフェンシン-2
Storage:
-20 ℃
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

CAS Registry Number:
120721-97-3
Category:
Biologically Active Peptides

reference

  1. T. Ganz, M.E. Selsted, D. Szklarek, S.S.L. Harwig, K. Daher, D.F. Bainton, and R.I. Lehrer, J. Clin. Invest., 76, 1427 (1985). (Original; Isolation)
  2. M.E. Selsted, S.S.L. Harwig, T. Ganz, J.W. Schilling, and R.I. Lehrer, J. Clin. Invest., 76, 1436 (1985). (Original; Structure)
  3. F.T. Lundy, D.F. Orr, J.R. Gallagher, P. Maxwell, C. Shaw, S.S. Napier, C.G. Cowan, P.-J. Lamey, and J.J. Marley, Oral Oncol., 40, 139 (2004). (Pharmacol.; HNP in Squamous Cell Carcinoma)
  4. F.T. Lundy, D.F. Orr, C. Shaw, P.-J. Lamey, and G.J. Linden, Mol. Immunol., 42, 575 (2005). (Pharmacol.; HNP in Gingival Crevicular Fluid)
  5. C. Kim, N. Gajendran, H.-W. Mittrüker, M. Weiwad, Y-H. Song, R. Hurwitz, M. Wilmanns, G. Fischer, and S.H.E. Kaufmann, Proc. Natl. Acad. Sci., U.S.A., 102, 4830 (2005). (Pharmacol.; Neutralization of Anthrax Lethal Toxin)
  6. C.B. Buck, P.M. Day, C.D. Thompson, J. Lubkowski, W. Lu, D.R. Lowy, and J.T. Schiller, Proc. Natl. Acad. Sci. U.S.A., 103, 1516 (2006). (Pharmacol.; Inhibition of Papillomavirus Infection)
  7. R.I. Lehrer, T. Ganz, D. Szklarek, and M.E. Selsted, J. Clin. Invest., 81, 1829 (1988). (Pharmacol.;Activity difference in HNP)
  8. S. Kubo, K. Tanimura, H. Nishio, N. Chino, T. Teshima, T. Kimura, and Y. Nishiuchi, Int. J. Pept. Res. Ther., 14, 341 (2008). (Chem. Synthesis & Pharmacol.)
  9. R.I. Lehrer and T. Ganz, Ann. N. Y. Acad. Sci., 797, 228 (1996). (Review)
  10. M. Zasloff, Nature, 415, 389 (2002). (Review)
  11. T. Hirsch, F. Jacobsen, H.-U. Steinau, and L. Steinstraesser, Protein Pept. Lett., 15, 238 (2008). (Review)
  12. M. Pazgier, X. Li, W. Lu, and J. Lubkowski, Curr. Pharm. Des., 13, 3096 (2007). (Review)
  13. Y. Lai and R.L. Gallo, Trends Immunol., 30, 131 (2009). (Review)