4410-s Muscarinic Toxin 3

Code:
4410-s
Name:
Muscarinic Toxin 3
MT3, MTX3, m4-toxin
Leu-Thr-Cys-Val-Thr-Lys-Asn-Thr-Ile-Phe-Gly-Ile-Thr-Thr-Glu-Asn-Cys-Pro-Ala-Gly-Gln-Asn-Leu-Cys-Phe-Lys-Arg-Trp-His-Tyr-Val-Ile-Pro-Arg-Tyr-Thr-Glu-Ile-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ile-Pro-Glu-Asn-Tyr-Asp-Ser-Ile-His-Cys-Cys-Lys-Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bonds between Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, and Cys58-Cys63)
(M.W. 7379.4) C319H489N89O97S8
Specific Ligand for Muscarinic Acetylcholine Receptor-4 (M4)
Package Price(Yen)
Vial 0.1 mg 30,000

main

Purity:
≧96.0% (HPLC)
Storage:
-20 ℃
Source:
Green Mamba, Dendroaspis angusticeps
Production:
Synthetic Product

Solubility: H2O (50 μM)

more information

Category:
Biologically Active Peptides

reference

  1. K.N. Bradley, Pharmacol. Ther., 85, 87 (2000). (Review)
  2. T.G. Beach, D.G. Walker, P.E. Potter, L.I. Sue, and A. Fisher, Brain Res., 905, 220 (2001). (Pharmacol.)
  3. C. Hock, A. Maddalena, A. Raschig, F. Müller-Spahn, G. Eschweiler, K. Hager, I. Heuser, H. Hampel, T. Müller-Thomsen, W. Oertel M. Wienrich, A. Signorell, C. Gonzalez-Agosti, and R.M. Nitsch, J. Protein Folding Disord., 10, 1 (2003). (Pharmacol.)
  4. Z. Gu, P. Zhong, and Z. Yan, J. Biol. Chem., 278, 17546 (2003). (Pharmacol; Inhibition of β -Amyloid signaling)
  5. S. Katayama, M. Ishimaru, H. Nishio, Y. Nishiuchi, and T. Kimura, Peptide Science 2004, 161 (2005). (S-S Bond)
  6. M. Jolkkonen, P.L.M. van Giersbergen, U. Hellman, C. Wernstedt, and E. Karlsson, FEBS Lett., 352, 91 (1994). (Original; MT3)
  7. J.-S. Liang, J. Carsi-Gabrenas, J.L. Krajewski, J.M. McCafferty, S.L. Purkerson, M.P. Santiago, W.L. Strauss, H.H. Valentine, and L.T. Potter, Toxicon, 34, 1257 (1996). (Original; m4-toxin)
  8. A. Adem and E. Karlsson, Life Sci., 60, 1069 (1997). (Pharmacol.; Muscarinic Receptor Subtype Specificity)
  9. M. C. Olianas, A. Adem, E. Karlsson, and P. Onali, Eur. J. Pharmacol., 357, 235 (1998). (Pharmacol.; cAMP-Coupled M4 Receptor)
  10. M. Jolkkonen, P.L.M. van Giersbergen, U. Hellman, C. Wernstedt, A. Oras, N. Satyapan, A. Adem, and E. Karlsson, Eur. J. Biochem., 234, 579 (1995). (Original)
  11. M. Jolkkonen, A. Oras, T. Toomela, E. Karlsson, J. Järv, and K.E.O. Åkerman, Toxicon, 39, 377 (2001). (Pharmacol; Mechanism of Receptor Binding)
  12. L.T. Potter, Life Sci., 68, 2541 (2001). (Review)
  13. D. Servent and C. Fruchart-Gaillard, J. Neurochem., 109, 1193 (2009). (Review)
  14. E. Karlsson, M. Jolkkonen, E. Mulugeta, P. Onali, and A. Adem, Biochimie, 82, 793 (2000). (Review)