4294-s ω-Agatoxin TK

Code:
4294-s
Name:
ω-Agatoxin TK
ω-Aga-TK
ω-Aga-IVB
Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-D-Ser-Phe-Ala (Reported disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36, and Cys27-Cys34)
(M.W. 5273.0) C215H337N65O70S10
P-type Ca2+ Channel Blocker
Package Price(Yen)
Vial 0.1 mg 30,000

main

Purity:
≧95.0% (HPLC)
Storage:
-20 ℃
Source:
Funnel Web Spider, Agelenopsis aperta
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

CAS Registry Number:
145017-83-0
Category:
Biologically Active Peptides

reference

  1. M. Kuwada, T. Teramoto, K.Y. Kumagaye, K. Nakajima, T. Watanabe, T. Kawai, Y. Kawakami, T. Niidome, K. Sawada, Y. Nishizawa, and K. Katayama, Mol. Pharmacol., 46, 587 (1994). (Original)
  2. Y. Shikata, T. Watanabe, T. Teramoto, A. Inoue, Y. Kawakami, Y. Nishizawa, K. Katayama, and M. Kuwada, J. Biol. Chem., 270, 16719 (1995). (L-Ser to D-Ser Isomerase)
  3. M.E. Adams, I.M. Mintz, M.D. Reily, V. Thanabal, and B.P. Bean, Mol. Pharmacol., 38, 681 (1990). (Original; ω-Aga-IVB)
  4. S.D. Heck, P.R. Kelbaugh, M.E. Kelly, P.F. Thadeio, N.A. Saccomano, J.G Stroh. and R.A. Volkmann, J. Am. Chem. Soc., 116, 10426 (1994). (S-S Bond; ω-Aga-IVB)
  5. T. Teramoto, T. Niidome, M. Kimura, M. Ohgoh, Y. Nishizawa, K. Katayama, T. Mayumi, and K. Sawada, Brain Res., 756, 225 (1997). (Pharmacol.)
  6. S.P. Lieske and J.-M. Ramirez, J. Neurophysiol., 95, 1323 (2006). (Pharmacol.)
  7. B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)
  8. O.D. Uchitel, Toxicon, 35, 1161 (1997). (Review)