4289-v ω-Conotoxin MVIIA

Code:
4289-v
Name:
ω-Conotoxin MVIIA
Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Reported disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25)
(M.W. 2639.1) C102H172N36O32S7
Reversible N-type Ca2+ Channel Blocker
Package Price(Yen)
Vial 0.5 mg 30,000

main

Purity:
≧98.0% (HPLC)
Other Name:
Ziconotide
Prialt
SNX-111
Storage:
-20 ℃
Source:
Marine Snail, Conus magus
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

CAS Registry Number:
107452-89-1
Category:
Biologically Active Peptides

reference

  1. B.M. Olivera, L.J. Cruz, V. de Santos, G.W. Le Cheminant, D. Griffin, R. Zeikus, J.M. McIntosh, R. Galyean, J. Varga, W.R. Gray, and J. Rivier, Biochemistry, 26, 2086 (1987). (Original)
  2. K. Valentino, R. Newcomb, T. Gadbois, T. Singh, S. Bowersox, S. Binter, A. Justice, D. Yamashiro, B.B. Hoffman, R. Ciaranello, G. Miljanich, and J. Ramachandran, Proc. Natl. Acad. Sci. USA, 90, 7894 (1993). (Pharmacol.)
  3. J.A. Fox, Pflügers Arch., 429, 873 (1995). (Pharmacol.)
  4. B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review)
  5. W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review)
  6. R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review)
  7. B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)