4435-s Psalmotoxin 1

Code:
4435-s
Name:
Psalmotoxin 1
PcTX1
Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr (Disulfide bonds between Cys3-Cys18, Cys10-Cys23, and Cys17-Cys33)
(Trifluoroacetate Form)
(M.W. 4689.4) C200H312N62O57S6
Selective Blocker for Acid-Sensitive Ion Channel, ASIC1a
Package Price(Yen)
Vial 0.1 mg 23,000

main

Purity:
≧97.0% (HPLC)
Storage:
-20 ℃
Source:
South American Tarantula, Psalmopoeus cambridgei
Production:
Synthetic Product

Solubility: H2O (0.1 mM)

more information

Category:
Biologically Active Peptides

reference

  1. P. Escoubas, J.R. De Weille, A. Lecoq, S. Diochot, R. Waldmann, G. Champigny, D. Moinier, A. Ménez, and M. Lazdunski, J. Biol. Chem., 275, 25116 (2000). (Original; Primary Structure & ASIC Blocking Selectivity)
  2. P. Escoubas, C. Bernard, G. Lambeau, M. Lazdunski, and H. Darbon, Protein Sci., 12, 1332 (2003). (Three-dimensional Solution Structure)
  3. X. Chen, H. Kalbacher, and S. Gründer, J. Gen. Physiol., 127, 267 (2006). (Pharmacol.; State-Dependent Function)
  4. X. Chen, H. Kalbacher, and S. Gründer, J. Gen. Physiol., 126, 71 (2005). (Pharmacol.; Mechanism of Channel Inhibition)
  5. J.K. Bubien, H.-L. Ji, G.Y. Gillespie, C.M. Fuller, J.M. Markert, T.B. Mapstone, and D.J. Benos, Am. J. Physiol., 287, C1282 (2004). (Pharmacol.; Inhibition of Malignant Glioma Na+ Channels)
  6. Z.-G. Xiong, X.-M. Zhu, X.-P. Chu, M. Minami, J. Hey, W.-L. Wei, J.F. MacDonald, J.A. Wemmie, M.P. Price, M.J. Welsh, and R.P. Simon, Cell, 118, 687 (2004). (Pharmacol.; Neuroprotection in Ischemia)
  7. S. Diochot, M. Salinas, A. Baron, P. Escoubas, and M. Lazdunski, Toxicon, 49, 271 (2007). (Review)
  8. Y.J. Qadri, B.K. Berdiev, Y. Song, H.L. Lippton, C.M. Fuller, and D.J. Benos, J. Biol. Chem., 284, 17625 (2009). (Pharmacol.)