4368-v Lactacystin

Code:
4368-v
Name:
Lactacystin
N-Acetyl-S-{(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl}-L-cysteine
(M.W. 376.43) C15H24N2O7S
Inhibitor for Proteasome
Package Price(Yen)
Vial 0.2 mg 20,000

main

Other Name:
ラクタシスチン
Storage:
-20 ℃
Production:
Microbial Product

Solubility: H2O (1 mM)

more information

Structure:
構造図Lactacystin
CAS Registry Number:
133343-34-7
Category:
Enzyme Inhibitors

reference

  1. S. Omura, T. Fujimoto, K. Otoguro, K. Matsuzaki, R. Moriguchi, H. Tanaka, and Y. Sasaki, J. Antibiotics, 44, 113 (1991). (Original)
  2. S. Omura, K. Matsuzaki, T. Fujimoto, K. Kosuge, T. Furuya, S. Fujita, and A. Nakagawa, J. Antibiotics, 44, 117 (1991). (Original; Chem. Structure)
  3. G. Fenteany, R.F. Standaert, W.S. Lane, S. Choi, E.J. Corey, and S.L. Schreiber, Science, 268, 726 (1995). (Biochem.; Proteasome Inhibition)
  4. S. Imajoh-Ohmi, T. Kawaguchi, S. Sugiyama, K. Tanaka, S. Omura, and H. Kikuchi, Biochem. Biophys. Res. Commun., 217, 1070 (1995). (Biochem.; Apoptotic Effect)
  5. D. Leung, G. Abbenante, and D.P. Fairlie, J. Med. Chem., 43, 305 (2000).