24018-s Lipid A (Alcaligenes faecalis)

Code:
24018-s
Name:
Lipid A (Alcaligenes faecalis)
2-[(R)-3-(Decanoyloxy)tetradecanoylamino]-2-deoxy-6-O-(2-deoxy-2-{(R)-3-[(R)-3-hydroxydodecanoyloxy]tetradecanoylamino}-3-O-[(R)-3-hydroxytetradecanoyl]-β-D-glucopyranosyl)-3-O-[(R)-3-hydroxytetradecanoyl]-α-D-glucopyranose 1,4′-bisphosphate
(Triethylammonium Form)
(M.W. 1758.3) C90H170N2O26P2
Vaccine Adjuvant Candidate / Active Principle of Low-Toxic Endotoxin
Package Price(Yen)
Vial 0.1 mg 25,000

main

Storage:
-20 ℃
Source:
Alcaligenes faecalis

Solubility: DMSO (0.1 mM)

more information

Structure:
構造図Lipid A (Alcaligenes faecalis)
CAS Registry Number:
2243645-00-1
Category:
Carbohydrates and Conjugates

This compound is distributed under the license of National Institutes of Biomedical Innovation, Health and Nutrition and The Research Foundation for Microbial Diseases of Osaka University.

reference

  1. Y. Wang, K. Hosomi, A. Shimoyama, K. Yoshii, H. Yamaura, T. Nagatake, T. Nishino, H. Kiyono, K. Fukase, and J. Kunisawa, Vaccines, 8, 395 (2020). (Adjuvant Activity)
  2. K. Yoshii, K. Hosomi, A. Shimoyama, Y. Wang, H. Yamaura, T. Nagatake, H. Suzuki, H. Lan, H. Kiyono, K. Fukase, and J. Kunisawa, Microorganisms, 8, 1102 (2020). (Adjuvant Activity)
  3. A. Shimoyama, F. Di Lorenzo, H. Yamaura, K. Mizote, A. Palmigiano, M.D. Pither, I. Speciale, T. Uto, S. Masui, L. Sturiale, D. Garozzo, K. Hosomi, N. Shibata, K. Kabayama, Y. Fujimoto, A. Silipo, J. Kunisawa, H. Kiyono, A. Molinaro, and K. Fukase, Angew. Chem. Int. Ed., 60, 10023 (2021). (Chem. Synthesis)