Peptide Institute

Code:	4455-s
Name:	Huwentoxin-IV
	HWTX-IV
Storage:
Production:	Synthetic Product
Source:	(Chinese Bird Spider, Ornithoctonus huwena)

Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Arg-Trp-Cys-Lys-Tyr-Gln-Ile-NH₂
(Disulfide bonds between Cys²-Cys¹⁷, Cys⁹-Cys²⁴, and Cys¹⁶-Cys³¹)

(Trifluoroacetate Form)

(M.W. 4106.80) C₁₇₄H₂₇₈N₅₂O₅₁S₆

Neuronal Tetrodotoxin-Sensitive Na⁺-Channel Blocker

References:

K. Peng, Q. Shu, Z. Liu, and S. Liang,J. Biol. Chem.,277,47564 (2002).(Original)

J. Diao, Y. Lin, J. Tang, and S. Liang,Toxicon,42,715 (2003).(cDNA Seq)

Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang, and T.R. Cummins,J. Biol. Chem.,283,27300 (2008).(Pharmacol.)

Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng, and S. Liang,Toxicon,51,230 (2008).(Pharmacol.)

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Package	Price(Yen)
Vial 0.1 mg	22,000